Resistive exercises, with or without whole body vibration, prevent vertebral marrow fat accumulation during 60 days of head-down tilt bed rest in men

Trudel, Guy, Coletta, Elizabeth, Cameron, Ian, Belavy, Daniel L., Lecompte, Martin, Armbrecht, Gabriele, Felsenberg, Dieter and Uhthoff, Hans K. 2012, Resistive exercises, with or without whole body vibration, prevent vertebral marrow fat accumulation during 60 days of head-down tilt bed rest in men, Journal of applied physiology, vol. 112, no. 11, pp. 1824-1831, doi: 10.1152/japplphysiol.00029.2012.

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Title Resistive exercises, with or without whole body vibration, prevent vertebral marrow fat accumulation during 60 days of head-down tilt bed rest in men
Author(s) Trudel, Guy
Coletta, Elizabeth
Cameron, Ian
Belavy, Daniel L.ORCID iD for Belavy, Daniel L. orcid.org/0000-0002-9307-832X
Lecompte, Martin
Armbrecht, Gabriele
Felsenberg, Dieter
Uhthoff, Hans K.
Journal name Journal of applied physiology
Volume number 112
Issue number 11
Start page 1824
End page 1831
Total pages 8
Publisher American Physiological Society
Place of publication Bethesada, Md.
Publication date 2012-06-01
ISSN 1522-1601
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Physiology
Sport Sciences
magnetic resonance imaging
erythrocytes
RANDOMIZED CONTROLLED-TRIAL
PROTON MR SPECTROSCOPY
BONE-MARROW
ADIPOSE-TISSUE
POSTURAL CONTROL
STEM-CELL
LEPTIN
ALTITUDE
YOUNG
AGE
Summary Fat accumulates in the bone marrow of lumbar vertebrae with bed rest. Exercise with or without whole body vibration may counter this effect. Our objectives were to measure 1) the vertebral fat fraction (VFF) of men subjected to bed rest who performed resistive exercises with (RVE, n = 7) or without whole body vibration(RE, n = 8) or no exercise (CTR, n = 9) using three MRI techniques; and 2) changes in peripheral blood counts. Twenty-four healthy men (age: 20-45 yr) underwent -6° head-down tilt (HDT) bed rest for 60 days. MRI was performed using three techniques (fat saturation, proton spectroscopy, and in and out of phase) to measure the fat fraction of L(3), L(4), and/or L(5) at baseline, mid-HDT, and end-HDT. Erythrocytes and leukocytes were counted at HDT days 19, 33, 47, 54, and 60. The mean absolute VFF was increased in the CTR group at mid-HDT and end-HDT (+3.9 ± 1.3 and +3.6 ± 1.2%, respectively, both P < 0.05). The RE group had a smaller VFF change than the CTR group at mid-HDT (-0.9 ± 1.2 vs. +3.9 ± 1.3%, P < 0.05). The RVE group had a smaller VFF change than the CTR group at end-HDT (-2.6 ± 1.9 vs. +3.5 ± 1.2%, P < 0.05). Erythrocyte counts were increased in all groups at HDT day 19 and HDT day 33 and in the RE group at HDT day 54 (all P < 0.05). Bed rest for 60 days at -6° HDT increased lumbar VFF in men beyond natural involution. RVE and RE regimens effectively prevented VFF accumulation. Higher erythrocyte counts were not altered by RVE or RE. Whole body vibration, along with RE administered to people with prolonged immobility, may prevent fat accumulation in their bone marrow.
Language eng
DOI 10.1152/japplphysiol.00029.2012
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071053

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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