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The 2nd Berlin BedRest Study: protocol and implementation

Belavý, D.L., Bock, O., Börst, H., Armbrecht, G., Gast, U., Degner, C., Beller, G., Soll, H., Salanova, M., Habazettl, H., Heer, M., de Haan, A., Stegeman, D.F., Cerretelli, P., Blottner, D., Rittweger, J., Gelfi, C., Kornak, U. and Felsenberg, D. 2010, The 2nd Berlin BedRest Study: protocol and implementation, Journal of musculoskeletal and neuronal interactions, vol. 10, no. 3, pp. 207-219.

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Title The 2nd Berlin BedRest Study: protocol and implementation
Author(s) Belavý, D.L.ORCID iD for Belavý, D.L. orcid.org/0000-0002-9307-832X
Bock, O.
Börst, H.
Armbrecht, G.
Gast, U.
Degner, C.
Beller, G.
Soll, H.
Salanova, M.
Habazettl, H.
Heer, M.
de Haan, A.
Stegeman, D.F.
Cerretelli, P.
Blottner, D.
Rittweger, J.
Gelfi, C.
Kornak, U.
Felsenberg, D.
Journal name Journal of musculoskeletal and neuronal interactions
Volume number 10
Issue number 3
Start page 207
End page 219
Total pages 13
Publisher International Society of Musculoskeletal and Neuronal Interactions
Place of publication Kifissia, Greece
Publication date 2010-09
ISSN 1108-7161
Keyword(s) Adult
Bed Rest
Berlin
Exercise Therapy
Humans
Male
Middle Aged
Osteoporosis
Physical Fitness
Treatment Outcome
Vibration
Weightlessness Simulation
Young Adult
Summary Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p < .0001), though similarly in all groups (p > or = .17). Body weight changes differed between groups (p < .0001) with decreases in the CTR-group, marginal decreases in the RE-group and the RVE-group displaying significant decreases in body-weight beyond bed-rest day-51 only. In light of events and experiences of the current study, recommendations on various aspects of bed-rest methodology are also discussed.
Language eng
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2010, International Society of Musculoskeletal and Neuronal Interactions
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071060

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.