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Trabecular and cortical bone density and architecture in women after 60 days of bed rest using high-resolution pQCT: WISE 2005

Armbrecht, Gabriele, Belavý, Daniel L., Backström, Magdalena, Beller, Gisela, Alexandre, Christian, Rizzoli, Rene and Felsenberg, Dieter 2011, Trabecular and cortical bone density and architecture in women after 60 days of bed rest using high-resolution pQCT: WISE 2005, Journal of bone and mineral research, vol. 26, no. 10, pp. 2399-2410, doi: 10.1002/jbmr.482.

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Title Trabecular and cortical bone density and architecture in women after 60 days of bed rest using high-resolution pQCT: WISE 2005
Author(s) Armbrecht, Gabriele
Belavý, Daniel L.ORCID iD for Belavý, Daniel L. orcid.org/0000-0002-9307-832X
Backström, Magdalena
Beller, Gisela
Alexandre, Christian
Rizzoli, Rene
Felsenberg, Dieter
Journal name Journal of bone and mineral research
Volume number 26
Issue number 10
Start page 2399
End page 2410
Total pages 12
Publisher Wiley
Place of publication London, Eng.
Publication date 2011-10
ISSN 1523-4681
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
MICROGRAVITY
OSTEOPOROSIS
BONE STRUCTURE
HIGH-RESOLUTION PQCT
3D PQCT
QUANTITATIVE COMPUTED-TOMOGRAPHY
NEGATIVE-PRESSURE EXERCISE
IN-VIVO
RESISTANCE EXERCISE
POSTMENOPAUSAL WOMEN
PROTEIN-INTAKE
STRAIN-RATE
BIOCHEMICAL MARKERS
UPRIGHT EXERCISE
CALCIUM BALANCE
Summary Prolonged bed rest is used to simulate the effects of spaceflight and causes disuse-related loss of bone. While bone density changes during bed rest have been described, there are no data on changes in bone microstructure. Twenty-four healthy women aged 25 to 40 years participated in 60 days of strict 6-degree head-down tilt bed rest (WISE 2005). Subjects were assigned to either a control group (CON, n = 8), which performed no countermeasures; an exercise group (EXE, n = 8), which undertook a combination of resistive and endurance training; or a nutrition group (NUT, n = 8), which received a high-protein diet. Density and structural parameters of the distal tibia and radius were measured at baseline, during, and up to 1 year after bed rest by high-resolution peripheral quantitative computed tomography (HR-pQCT). Bed rest was associated with reductions in all distal tibial density parameters (p < 0.001), whereas only distal radius trabecular density decreased. Trabecular separation increased at both the distal tibia and distal radius (p < 0.001), but these effects were first significant after bed rest. Reduction in trabecular number was similar in magnitude at the distal radius (p = 0.021) and distal tibia (p < 0.001). Cortical thickness decreased at the distal tibia only (p < 0.001). There were no significant effects on bone structure or density of the countermeasures (p ≥ 0.057). As measured with HR-pQCT, it is concluded that deterioration in bone microstructure and density occur in women during and after prolonged bed rest. The exercise and nutrition countermeasures were ineffective in preventing these changes.
Language eng
DOI 10.1002/jbmr.482
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, American Society for Bone and Mineral Research
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071068

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