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WISE-2005: bed-rest induced changes in bone mineral density in women during 60 days simulated microgravity

Beller, Gisela, Belavý, Daniel L., Sun, Lianwen, Armbrecht, Gabriele, Alexandre, Christian and Felsenberg, Dieter 2011, WISE-2005: bed-rest induced changes in bone mineral density in women during 60 days simulated microgravity, Bone, vol. 49, no. 4, pp. 858-866, doi: 10.1016/j.bone.2011.06.021.

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Title WISE-2005: bed-rest induced changes in bone mineral density in women during 60 days simulated microgravity
Author(s) Beller, Gisela
Belavý, Daniel L.ORCID iD for Belavý, Daniel L. orcid.org/0000-0002-9307-832X
Sun, Lianwen
Armbrecht, Gabriele
Alexandre, Christian
Felsenberg, Dieter
Journal name Bone
Volume number 49
Issue number 4
Start page 858
End page 866
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2011-10
ISSN 1873-2763
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Microgravity
Spaceflight
pQCT
DXA
Bone mineral density
BODY NEGATIVE-PRESSURE
RESISTIVE VIBRATION EXERCISE
SPINAL-CORD-INJURY
HEAD-DOWN TILT
RESISTANCE EXERCISE
MUSCLE ATROPHY
TREADMILL EXERCISE
LOWER-EXTREMITIES
UPRIGHT EXERCISE
RESPONSE VARIES
Summary To better understand the effects of prolonged bed-rest in women, 24 healthy women aged 25 to 40 years participated in 60-days of strict 6° head-down tilt bed-rest (WISE-2005). Subjects were assigned to either a control group (CON, n=8) which performed no countermeasure, an exercise group (EXE, n=8) undertaking a combination of resistive and endurance training or a nutrition group (NUT, n=8), which received a high protein diet. Using peripheral quantitative computed tomography (pQCT) and dual X-ray absorptiometry (DXA), bone mineral density (BMD) changes at various sites, body-composition and lower-leg and forearm muscle cross-sectional area were measured up to 1-year after bed-rest. Bone loss was greatest at the distal tibia and proximal femur, though losses in trabecular density at the distal radius were also seen. Some of these bone losses remained statistically significant one-year after bed-rest. There was no statistically significant impediment of bone loss by either countermeasure in comparison to the control-group. The exercise countermeasure did, however, reduce muscle cross-sectional area and lean mass loss in the lower-limb and also resulted in a greater loss of fat mass whereas the nutrition countermeasure had no impact on these parameters. The findings suggest that regional differences in bone loss occur in women during prolonged bed-rest with incomplete recovery of this loss one-year after bed-rest. The countermeasures as implemented were not optimal in preventing bone loss during bed-rest and further development is required.
Language eng
DOI 10.1016/j.bone.2011.06.021
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071072

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