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Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc

Kanwar,JR, Mahidhara,G, Roy,K, Sasidharan,S, Krishnakumar,S, Prasad,N, Sehgal,R and Kanwar,RK 2015, Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc, Nanomedicine, vol. 10, no. 1, pp. 35-55, doi: 10.2217/nnm.14.132.

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Title Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zinc
Author(s) Kanwar,JR
Mahidhara,G
Roy,K
Sasidharan,S
Krishnakumar,S
Prasad,N
Sehgal,R
Kanwar,RK
Journal name Nanomedicine
Volume number 10
Issue number 1
Start page 35
End page 55
Total pages 21
Publisher Future Medicine
Place of publication London, United Kingdom
Publication date 2015-01
ISSN 1748-6963
Keyword(s) Fe-bLf
absorption
iron metabolism
miRNA
nanocarriers/nanocapsules
nanotoxicity
oral delivery
stem cell
survivin
xenograft
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Nanoscience & Nanotechnology
Science & Technology - Other Topics
nanocarriers
nanocapsules
ANTIOXIDANT ENZYME-ACTIVITIES
GUT EPITHELIAL-CELLS
TRANSFERRIN RECEPTOR
OXIDATIVE STRESS
DRUG-DELIVERY
TRANSPORTER 1
CACO-2 CELLS
NUDE-MICE
IN-VITRO
Summary To validate the anticancer efficacy of alginate-enclosed, chitosan-conjugated, calcium phosphate, iron-saturated bovine lactoferrin (Fe-bLf) nanocarriers/nanocapsules (NCs) with improved sustained release and ability to induce apoptosis by downregulating survivin, as well as cancer stem cells.
Language eng
DOI 10.2217/nnm.14.132
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Future Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071104

Document type: Journal Article
Collection: School of Medicine
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