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A comparison of olanzapine with haloperidol in cannabis-induced psychotic disorder: a double-blind randomized controlled trial

Berk, M., Brook, S. and Trandafir, A. I. 1999, A comparison of olanzapine with haloperidol in cannabis-induced psychotic disorder: a double-blind randomized controlled trial, International clinical psychopharmacology, vol. 14, no. 3, pp. 177-180.

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Title A comparison of olanzapine with haloperidol in cannabis-induced psychotic disorder: a double-blind randomized controlled trial
Author(s) Berk, M.ORCID iD for Berk, M. orcid.org/0000-0002-5554-6946
Brook, S.
Trandafir, A. I.
Journal name International clinical psychopharmacology
Volume number 14
Issue number 3
Start page 177
End page 180
Publisher Lippincott Williams & Wilkins
Place of publication London, Eng.
Publication date 1999-05
ISSN 0268-1315
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Psychiatry
PSYCHIATRY, SCI
olanzapine
psychosis
schizophrenia
Summary Little controlled data exist on the treatment of substance induced psychotic disorders. In this study, 30 patients meeting DSM-IV criteria for cannabis induced psychotic disorder were randomly allocated to receive either olanzapine or haloperidol in a 4-week double-blind clinical trial. There were no significant outcome differences between the two groups on any of the primary outcome measures, the Brief Psychiatric Rating Scale (haloperidol 25.7; olanzapine 27.1; P = 0.70); Clinical Global Impression (CGI) severity scale (haloperidol 1.8, olanzapine 2.3; P = 0.21) or the CGI improvement scale (haloperidol 1.3, olanzapine 1.7; P = 0.16). The haloperidol group however, developed significantly more extrapyramidal side-effects as measured by the Simpson Angus Scale (haloperidol 11.4, olanzapine 2.5; P = 0.014). Significantly (P = 0.027) more biperidin was used for extrapyramidal side-effects in the haloperidol (7.143 mg) than in the olanzapine (0.357 mg) group. Olanzapine appears to be as effective as haloperidol in the treatment of cannabis induced psychotic disorder, but is associated with a lower rate of extrapyramidal side-effects.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071133

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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