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Associations of obsessive-compulsive symptoms with clinical and neurocognitive features in schizophrenia according to stage of illness

Kim, Sung-Wan, Jeong, Bo-Ok, Kim, Jae-Min, Shin, II-Seon, Hwang, Michael Y., Amminger, G. Paul, Nelson, Barnaby, Berk, Michael, McGorry, Patrick and Yoon, Jin-Sang 2015, Associations of obsessive-compulsive symptoms with clinical and neurocognitive features in schizophrenia according to stage of illness, Psychiatry research, vol. 226, no. 1, pp. 368-375, doi: 10.1016/j.psychres.2015.01.021.

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Title Associations of obsessive-compulsive symptoms with clinical and neurocognitive features in schizophrenia according to stage of illness
Author(s) Kim, Sung-Wan
Jeong, Bo-Ok
Kim, Jae-Min
Shin, II-Seon
Hwang, Michael Y.
Amminger, G. Paul
Nelson, Barnaby
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
McGorry, Patrick
Yoon, Jin-Sang
Journal name Psychiatry research
Volume number 226
Issue number 1
Start page 368
End page 375
Total pages 8
Publisher Elsevier
Place of publication Shannon, Ireland
Publication date 2015-03-30
ISSN 1872-7123
Keyword(s) cognition
comorbidity
depression
obsessive–compulsive symptoms
quality of life
schizophrenia
obsessive-compulsive symptoms
Summary This study aimed to investigate the association of obsessive-compulsive symptoms with clinical and neurocognitive features in patients with schizophrenia. This study enrolled 163 people with schizophrenia who were receiving risperidone monotherapy. Comorbid obsessive-compulsive symptoms were assessed using the Yale-Brown Obsessive-Compulsive Scale, and subjects with a score ≥ 10 constituted the obsessive-compulsive symptom group (n=30, 18.4%). The learning index was significantly higher in patients with obsessive-compulsive symptoms than in those without such symptoms after adjusting for age, stage (early and chronic), duration of illness, and CDSS score. However, there was no significant interaction between obsessive-compulsive symptoms and stage of illness. Scores on Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia, and Beck Depression Inventory were significantly higher in the obsessive-compulsive symptom group. In addition, the Subjective Well-being under Neuroleptic Treatment score was significantly lower in the obsessive-compulsive symptom group. In conclusion, comorbid obsessive-compulsive symptoms in patients with schizophrenia were associated with a higher learning ability without a significant interaction with stage of illness. However, schizophrenia patients with obsessive-compulsive symptoms had more severe psychotic and depressive symptoms and poorer quality of life.
Language eng
DOI 10.1016/j.psychres.2015.01.021
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071139

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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