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Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications

Aggarwal, Shilpa, Dodd, Seetal and Berk, Michael 2015, Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications, Current drug safety, vol. 10, no. 2, pp. 98-105.

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Title Restless leg syndrome associated with atypical antipsychotics : current status, pathophysiology, and clinical implications
Author(s) Aggarwal, Shilpa
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Current drug safety
Volume number 10
Issue number 2
Start page 98
End page 105
Total pages 8
Publisher Bentham Science Publishers
Place of publication San Francisco, Calif.
Publication date 2015-07
ISSN 1574-8863
2212-3911
Summary Restless leg syndrome (RLS) is a common disorder, frequently of unclear origin, which is often associated with significant distress. There are a few case reports of atypical antipsychotic agents (AAP) causing RLS. The pathophysiological mechanisms resulting in emergence of these movements suggest central dopaminergic dysfunction. Dopamine agonists and L-dopa reduce the symptoms of RLS, and some agents that block the dopaminergic system aggravate RLS. Genetic influences are implicated in RLS and an association between gene polymorphisms and antipyschotic-associated onset of RLS has been postulated. Greater awareness of potential causes of RLS, and its differentiation from akathisia and illness-related agitation might help in reducing the distress associated with it and improving patient compliance in patients using atypical antipsychotic agents.
Language eng
Field of Research 110319 Psychiatry (incl Psychotherapy)
111714 Mental Health
1115 Pharmacology And Pharmaceutical Sciences
1103 Clinical Sciences
1104 Complementary And Alternative Medicine
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071223

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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