The platelet intracellular calcium response to serotonin and thrombin in patients with panic disorder.

Plein,H and Berk,M 1999, The platelet intracellular calcium response to serotonin and thrombin in patients with panic disorder., European Neuropsychopharmacology, vol. 9, no. 1-2, pp. 107-110.

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Title The platelet intracellular calcium response to serotonin and thrombin in patients with panic disorder.
Author(s) Plein,H
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Journal name European Neuropsychopharmacology
Volume number 9
Issue number 1-2
Start page 107
End page 110
Publisher Elsevier
Place of publication NETHERLANDS
Publication date 1999-01
ISSN 0924-977X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pharmacology & Pharmacy
Psychiatry
Neurosciences & Neurology
PSYCHIATRY, SCI
platelet intracellular calcium response
PSYCHIATRIC-DISORDERS
DEPRESSED-PATIENTS
MOBILIZATION
NEUROENDOCRINE
ANXIETY
Summary Serotonin is implicated in both the biology of depression and anxiety. The aim of this study was to examine the platelet intracellular calcium response to serotonin and thrombin using spectrofluorometry in 14 patients with DSM-4 panic disorder compared to 14 matched controls. Patients did not show significantly higher baseline platelet intracellular calcium levels and serotonin stimulated levels of intracellular calcium than control subjects. There was a much smaller standard deviation in the control subjects than in the panic patients. The intracellular calcium response to thrombin activation was however greater in panic patients than in control subjects (P<0.001). The failure of this study to find enhanced sensitivity of 5-HT2 receptors in panic disorder is compatible with the findings of previous challenge studies that found no consistent dysregulation of serotonin in panic disorder. The enhanced thrombin sensitivity, nevertheless suggests some receptor mediated second messenger changes independent of serotonin in the disorder.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071262

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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