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The prolactin response to sulpiride in major depression: the role of the D2 receptor in depression.

Verbeeck,WJ, Berk,M, Paiker,J and Jersky,B 2001, The prolactin response to sulpiride in major depression: the role of the D2 receptor in depression., European Neuropsychopharmacology, vol. 11, no. 3, pp. 215-220.

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Title The prolactin response to sulpiride in major depression: the role of the D2 receptor in depression.
Author(s) Verbeeck,WJ
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Paiker,J
Jersky,B
Journal name European Neuropsychopharmacology
Volume number 11
Issue number 3
Start page 215
End page 220
Publisher Elsevier
Place of publication Netherlands
Publication date 2001-06
ISSN 0924-977X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pharmacology & Pharmacy
Psychiatry
Neurosciences & Neurology
PSYCHIATRY, SCI
POSITRON-EMISSION-TOMOGRAPHY
IN-VIVO
DOPAMINE LEVELS
BINDING
PLACEBO
SEROTONIN
DISORDER
ANTIDEPRESSANTS
METOCLOPRAMIDE
AMITRIPTYLINE
Summary Multiple lines of investigations have implicated the role of the dopaminergic system in depression. The aim of the study was to characterise the Dopamine D2 receptor sensitivity status in depressed patients versus controls by means of a novel neuro-endocrine challenge test, the prolactin response to sulpiride. In this intervention, ten patients and ten age matched male volunteers were studied. The patients were diagnosed according to DSM-IV criteria, and Montgomery Asberg and Zung scales were done. There was no significant difference in baseline levels of prolactin between the depressed and control groups. Significantly higher prolactin levels after sulpiride challenge were however found in depressed patients than controls at all time points after sulpiride administration. This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls. This adds to the data implicating the dopaminergic system in the pathophysiology of depression, and suggests that dopaminergic mechanisms might be a target of therapeutic interest.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071267

Document type: Journal Article
Collection: School of Medicine
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