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The role of lamotrigine in the management of bipolar disorder.

Ng,F, Hallam,K, Lucas,N and Berk,M 2007, The role of lamotrigine in the management of bipolar disorder., Neuropsychiatric Disease and Treatment, vol. 3, no. 4, pp. 463-474.

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Title The role of lamotrigine in the management of bipolar disorder.
Author(s) Ng,F
Hallam,K
Lucas,N
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Journal name Neuropsychiatric Disease and Treatment
Volume number 3
Issue number 4
Start page 463
End page 474
Publisher Dove Medical Press
Place of publication New Zealand
Publication date 2007-08
ISSN 1176-6328
Keyword(s) Lamotrigine
bipolar depression
bipolar disorder
clinical trials
efficacy
Summary Lamotrigine has emerged with a distinct place in the pharmacological treatment of bipolar disorder, with the potential to treat and prevent bipolar depression, which is the dominant and arguably most disabling and under-treated phase of the illness. This review examines the published clinical trials of lamotrigine in bipolar treatment. While the data supports its tolerability and safety, the strongest evidence for its efficacy lies in the prevention of bipolar depression, with weaker evidence for the treatment of acute bipolar depression, refractory unipolar and bipolar depression, and rapid cycling bipolar disorder. The total number of published well designed trials is small, even the maintenance evidence is derived from two studies. However, this relative inadequacy compares favorably with the alternative treatment options for bipolar depression, which are marked by poor efficacy or risk of polarity switch. The designation of lamotrigine as first-line treatment for bipolar depression prophylaxis should be done in cognizance of this context, and it would seem prudent to await greater evidence of efficacy before designating lamotrigine as first-line treatment for other bipolar indications. Further randomized controlled trials are required to consolidate the available findings and to explore the boundaries of lamotrigine's efficacy, which may encompass the soft spectral disorders.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, Dove Medical Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071269

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.