The specificity of platelet glutamate receptor supersensitivity in psychotic disorders.

Berk,M, Plein,H and Belsham,B 2000, The specificity of platelet glutamate receptor supersensitivity in psychotic disorders., Life Sciences, vol. 66, no. 25, pp. 2427-2432.

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Title The specificity of platelet glutamate receptor supersensitivity in psychotic disorders.
Author(s) Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Plein,H
Belsham,B
Journal name Life Sciences
Volume number 66
Issue number 25
Start page 2427
End page 2432
Publisher Elsevier
Place of publication England
Publication date 2000
ISSN 0024-3205
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Pharmacology & Pharmacy
Research & Experimental Medicine
schizophrenia
mania
depression
psychosis
platelet intracellular calcium response
glutamate
receptor supersensitivity
INTRACELLULAR CALCIUM
DOUBLE-BLIND
MODEL
SEROTONIN
GLYCINE
Summary Hypoglutamatergic function is implicated in the pathogenesis of schizophrenia, and supersensitivity of platelet NMDA receptors has been reported in schizophrenia. The aim of this study was to examine the platelet glutamate receptor sensitivity in patients with schizophrenia (n=12), mania with psychotic features (n=10) and depression with psychotic features (n=10) and matched controls (n=12) in order to assess if this is a marker of schizophrenia or occurs in other psychotic conditions. Glutamate receptor sensitivity was assessed using the intracellular calcium response to glutamate measured with spectrofluorometry. The percentage response of the schizophrenic and depressed psychotic subjects to glutamate stimulation was significantly greater than control subjects (p<0.005). The mania with psychotic features group was not significantly different to controls. This data suggests that platelet glutamate receptors may be supersensitive in schizophrenia and depression with psychotic features. Furthermore, the platelet may be a possible peripheral marker of glutamate function in schizophrenia and depression with psychotic features.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2000, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071270

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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