Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and 45Ca2+ uptake.

Plein,H, Berk,M, Eppel,S and Butkow,N 2000, Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and 45Ca2+ uptake., Life Sciences, vol. 66, no. 5, pp. 425-431.

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Title Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and 45Ca2+ uptake.
Author(s) Plein,H
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Eppel,S
Butkow,N
Journal name Life Sciences
Volume number 66
Issue number 5
Start page 425
End page 431
Publisher Elsevier
Place of publication England
Publication date 2000
ISSN 0024-3205
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Pharmacology & Pharmacy
Research & Experimental Medicine
platelet
Ca-45(2+) uptake
major depression
intracellular Mn2+ influx
PLASMA-MEMBRANE
CA-2+ INFLUX
DISORDERS
MODEL
Summary There is an augmented platelet intracellular calcium response to serotonin stimulation in major depression. The role that calcium influx has in this process is not known. The objective of this study was to determine platelet calcium influx in response to serotonin by two methods, Mn2+ influx and 45Ca2+ uptake, in order to observe if the uptake response to serotonin was augmented in major depression by comparing the response to normal controls. The use of the two methods of calcium influx showed that serotonin stimulates calcium uptake into platelets. Furthermore, patients with major depression have significantly augmented platelet calcium uptake in response to serotonin. The interesting finding was that calcium uptake into platelets is biphasic, occurring immediately and after five minutes. These results may support the two pool model for calcium oscillations within cells whereby extracellular calcium is needed for intracellular calcium release, and for replenishment of depleted stores once intracellular calcium is released.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2000, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071281

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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