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Blunted adenosine A2a receptor function in platelets in patients with major depression.

Berk,M, Plein,H, Ferreira,D and Jersky,B 2001, Blunted adenosine A2a receptor function in platelets in patients with major depression., European Neuropsychopharmacology, vol. 11, no. 2, pp. 183-186.

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Title Blunted adenosine A2a receptor function in platelets in patients with major depression.
Author(s) Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Plein,H
Ferreira,D
Jersky,B
Journal name European Neuropsychopharmacology
Volume number 11
Issue number 2
Start page 183
End page 186
Publisher Elsevier
Place of publication Netherlands
Publication date 2001-04
ISSN 0924-977X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pharmacology & Pharmacy
Psychiatry
Neurosciences & Neurology
PSYCHIATRY, SCI
depression
mood
adenosine A2a receptor
intracellular signalling
GENERATION
INHIBITION
MECHANISMS
GENE
Summary There is provisional evidence of involvement of adenosine in depression. In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically significantly blunted second messenger response to agonist stimulation in the depressed group compared to the control group at the 50 and 100 nM and 1 microM dosage levels. This suggests that dysregulation of the adenosine A2a receptor may be present in depression.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C4.1 Letter or note
Copyright notice ©2001, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071288

Document type: Journal Article
Collection: School of Medicine
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