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Changes in the platelet intracellular calcium response to serotonin in patients with major depression treated with electroconvulsive therapy: state or trait marker status.

Plein,H and Berk,M 2000, Changes in the platelet intracellular calcium response to serotonin in patients with major depression treated with electroconvulsive therapy: state or trait marker status., International Clinical Psychopharmacology, vol. 15, no. 2, pp. 93-98.

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Title Changes in the platelet intracellular calcium response to serotonin in patients with major depression treated with electroconvulsive therapy: state or trait marker status.
Author(s) Plein,H
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Journal name International Clinical Psychopharmacology
Volume number 15
Issue number 2
Start page 93
End page 98
Publisher Lippincott, Williams & Wilkins
Place of publication England
Publication date 2000-03
ISSN 0268-1315
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Psychiatry
PSYCHIATRY, SCI
peripheral marker
platelet
receptor
serotonin
5-HT2 RECEPTOR-BINDING
ANTIDEPRESSANT TREATMENTS
BLOOD-PLATELETS
UP-REGULATION
BRAIN
DRUGS
FENFLURAMINE
MECHANISM
PROLACTIN
NEURONS
Summary Platelet serotonin type 2A receptor (5-HT2A) sensitivity changes have previously been documented in depression, although it is unclear if this represents a stable trait marker of the illness, or whether it represents an acute state marker of depression that would change with treatment. Electroconvulsive therapy (ECT) may be a useful intervention to separate out trait and state marker status avoiding the potential confounding effects of pharmacotherapy on receptor function. Using spectrofluorometry, the platelet 5HT2A, receptor sensitivity as reflected by the intracellular calcium response to serotonin stimulation, was measured every week in patients suffering from major depression and undergoing ECT. There was a significant drop in the platelet response to serotonin stimulation over a course of ECT, with an associated progressive decrease in Hamilton Rating Scale of Depression (HAM-D) scores. This may suggest either decreased sensitivity of platelet 5HT2A receptors as a mechanism of action of ECT, or changes in second messengers such as the inositide phospholipid system. This suggests that the enhanced sensitivity of platelet 5HT2A receptors may be a state marker of major depression.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2000, Lippincott, Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071289

Document type: Journal Article
Collection: School of Medicine
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