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DNA damage in rats after treatment with methylphenidate.

Andreazza,AC, Frey,BN, Valvassori,SS, Zanotto,C, Gomes,KM, Comim,CM, Cassini,C, Stertz,L, Ribeiro,LC, Quevedo,J, Kapczinski,F, Berk,M and Gonçalves,CA 2007, DNA damage in rats after treatment with methylphenidate., Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 31, no. 6, pp. 1282-1288, doi: 10.1016/j.pnpbp.2007.05.012.

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Title DNA damage in rats after treatment with methylphenidate.
Author(s) Andreazza,AC
Frey,BN
Valvassori,SS
Zanotto,C
Gomes,KM
Comim,CM
Cassini,C
Stertz,L
Ribeiro,LC
Quevedo,J
Kapczinski,F
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Gonçalves,CA
Journal name Progress in Neuro-Psychopharmacology & Biological Psychiatry
Volume number 31
Issue number 6
Start page 1282
End page 1288
Publisher Elsevier
Place of publication England
Publication date 2007-08
ISSN 0278-5846
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pharmacology & Pharmacy
Psychiatry
Neurosciences & Neurology
PSYCHIATRY, SCI
attention-deficit hyperactivity disorder
micronucleus test
oxidative stress
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
DEFICIT HYPERACTIVITY DISORDER
CELL GEL-ELECTROPHORESIS
IN-VITRO
DOPAMINE
CHILDREN
ASSAY
CATECHOLAMINES
ADOLESCENTS
Summary Methylphenidate (MPH) is a widely prescribed psychostimulant for the treatment of attention-deficit hyperactivity disorder (ADHD). Recently, some studies have addressed the genotoxic potential of the MPH, but the results have been contradictory. Hence, the present study aimed to investigate the index of cerebral and peripheral DNA damage in young and adult rats after acute and chronic MPH exposure.
Language eng
DOI 10.1016/j.pnpbp.2007.05.012
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071299

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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