Lamotrigine and the treatment of mania in bipolar disorder

Berk, M. 1999, Lamotrigine and the treatment of mania in bipolar disorder, European neuropsychopharmacology, vol. 9, no. Suppl 4, pp. S119-S123.

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Title Lamotrigine and the treatment of mania in bipolar disorder
Author(s) Berk, M.ORCID iD for Berk, M.
Journal name European neuropsychopharmacology
Volume number 9
Issue number Suppl 4
Start page S119
End page S123
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 1999-08
ISSN 0924-977X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Pharmacology & Pharmacy
Neurosciences & Neurology
controlled trial
Summary Anticonvulsants, including valproate and carbamazepine, have established efficacy in the treatment of mania. The anticonvulsant, lamotrigine. has been reported to have antimanic and antidepressant efficacy, and mood-stabilising effects in case reports and preliminary open trials. The efficacy and tolerability of lamotrigine has been compared with olanzapine and lithium in a randomised, prospective, controlled fashion over a period of 4 weeks treatment in a total of 45 hospitalised patients with DSM-IV-defined mania. Significant improvements of a similar magnitude were observed for all treatment groups and lamotrigine was well tolerated. Mechanisms of action proposed to explain the antimanic activity of lamotrigine include inhibition of voltage-sensitive and use-dependent sodium channels, inhibition of glutamate release and calcium channel blockade. Platelet studies have indicated supersensitivity of glutamate receptors and increased intracellular calcium concentrations in patients with mania. Further clinical and mechanistic studies of lamotrigine use in mania are warranted.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C2.1 Other contribution to refereed journal
Copyright notice ©1999, Elsevier
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Document type: Journal Article
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