You are not logged in.

Lamotrigine and the treatment of mania in bipolar disorder

Berk, M. 1999, Lamotrigine and the treatment of mania in bipolar disorder, European neuropsychopharmacology, vol. 9, no. Suppl 4, pp. S119-S123.

Attached Files
Name Description MIMEType Size Downloads

Title Lamotrigine and the treatment of mania in bipolar disorder
Author(s) Berk, M.ORCID iD for Berk, M. orcid.org/0000-0002-5554-6946
Journal name European neuropsychopharmacology
Volume number 9
Issue number Suppl 4
Start page S119
End page S123
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 1999-08
ISSN 0924-977X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pharmacology & Pharmacy
Psychiatry
Neurosciences & Neurology
PSYCHIATRY, SCI
lamotrigine
mania
controlled trial
tolerability
mechanisms
AFFECTIVE-ILLNESS
VALPROATE
EFFICACY
DEPRESSION
EPILEPSY
DRUG
Summary Anticonvulsants, including valproate and carbamazepine, have established efficacy in the treatment of mania. The anticonvulsant, lamotrigine. has been reported to have antimanic and antidepressant efficacy, and mood-stabilising effects in case reports and preliminary open trials. The efficacy and tolerability of lamotrigine has been compared with olanzapine and lithium in a randomised, prospective, controlled fashion over a period of 4 weeks treatment in a total of 45 hospitalised patients with DSM-IV-defined mania. Significant improvements of a similar magnitude were observed for all treatment groups and lamotrigine was well tolerated. Mechanisms of action proposed to explain the antimanic activity of lamotrigine include inhibition of voltage-sensitive and use-dependent sodium channels, inhibition of glutamate release and calcium channel blockade. Platelet studies have indicated supersensitivity of glutamate receptors and increased intracellular calcium concentrations in patients with mania. Further clinical and mechanistic studies of lamotrigine use in mania are warranted.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C2.1 Other contribution to refereed journal
Copyright notice ©1999, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071316

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 32 times in TR Web of Science
Scopus Citation Count Cited 57 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 16 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 18 Mar 2015, 10:14:50 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.