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Platelet glutamate receptor supersensitivity in major depressive disorder.

Berk,M, Plein,H and Ferreira,D 2001, Platelet glutamate receptor supersensitivity in major depressive disorder., Clinical Neuropharmacology, vol. 24, no. 3, pp. 129-132.

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Title Platelet glutamate receptor supersensitivity in major depressive disorder.
Author(s) Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Plein,H
Ferreira,D
Journal name Clinical Neuropharmacology
Volume number 24
Issue number 3
Start page 129
End page 132
Publisher Lippincott, Williams & Wilkins
Place of publication United States
Publication date 2001-05
ISSN 0362-5664
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Pharmacology & Pharmacy
Neurosciences & Neurology
depression
psychosis
platelet intracellular calcium response
glutamate
receptor supersensitivity
mood
N-methyl-D-aspartate
EXCITATORY AMINO-ACIDS
D-ASPARTATE RECEPTORS
INTRACELLULAR CALCIUM
SCHIZOPHRENIC-PATIENTS
DOUBLE-BLIND
MODEL
ANTIDEPRESSANTS
SEROTONIN
GLYCINE
PLASMA
Summary Dysregulation of glutamate has been described in depression, and supersensitivity of platelet glutamate receptors has been found in both psychotic major depression and schizophrenia. The aim of this study was to examine the platelet glutamate receptor sensitivity in patients with nonpsychotic, unipolar major depression to assess whether this is a marker of depression or of psychosis. Glutamate receptor sensitivity was assessed using the platelet intracellular calcium response to glutamate (0-100 micromol) measured by spectrofluorometry. The depression group showed a significantly greater platelet intracellular calcium response to glutamate stimulation than the control group, both in terms of absolute values (p = 0.007) and percentage of response from baseline (p = 0.030). These data suggest that platelet glutamate receptors may be supersensitive in depression and that the platelet may be a possible peripheral marker of glutamate function in depression.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, Lippincott, Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071328

Document type: Journal Article
Collection: School of Medicine
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