Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder.

Gama,CS, Andreazza,AC, Kunz,M, Berk,M, Belmonte-de-Abreu,PS and Kapczinski,F 2007, Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder., Neuroscience Letters, vol. 420, no. 1, pp. 45-48, doi: 10.1016/j.neulet.2007.04.001.

Attached Files
Name Description MIMEType Size Downloads

Title Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder.
Author(s) Gama,CS
Andreazza,AC
Kunz,M
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Belmonte-de-Abreu,PS
Kapczinski,F
Journal name Neuroscience Letters
Volume number 420
Issue number 1
Start page 45
End page 48
Publisher Elsevier
Place of publication Ireland
Publication date 2007-06
ISSN 1872-7972
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
antipsychotics
ESTIMATE LIFETIME DIAGNOSES
FACTOR BDNF GENE
VAL66MET POLYMORPHISM
OPCRIT DIAGNOSES
RATING-SCALE
ASSOCIATION
EXPRESSION
HIPPOCAMPUS
METAANALYSIS
Summary There is evidence that major psychiatric discords such as schizophrenia (SZ) and bipolar disorder (BD) are associated with dysregulation of synaptic plasticity with downstream alterations of neurotrophins. Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system (CNS), and performs many biological functions such as promoting the survival, differentiation, and plasticity of neurons. Variants in the BDNF gene increase the risk of SZ and bipolar disorder. Chronic administration of drugs used to treat SZ and BD, such as lithium, valproate, quetiapine, clozapine, and olanzapine, increases BDNF expression in rat brain. To examine serum BDNF, three groups of chronically medicated DSM-IV SZ patients, on treatment with clozapine (n=27), typical (n=14), and other atypical antipsychotics (n=19), 30 euthymic BD patients, and 26 healthy control had 5 ml blood samples collected by venipuncture. Serum BDNF levels were significantly higher in SZ patients (p<0.001) when compared to either controls or euthymic BD patients. Increased BDNF in SZ patients might be related to the course of illness or to treatment variables. Prospective studies are warranted.
Language eng
DOI 10.1016/j.neulet.2007.04.001
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071341

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 113 times in TR Web of Science
Scopus Citation Count Cited 121 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 346 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 18 Mar 2015, 10:29:00 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.