Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia.

Berk,M, Plein,H and Csizmadia,T 1999, Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia., International Clinical Psychopharmacology, vol. 14, no. 2, pp. 119-122.

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Title Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia.
Author(s) Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Plein,H
Csizmadia,T
Journal name International Clinical Psychopharmacology
Volume number 14
Issue number 2
Start page 119
End page 122
Publisher Lippincott, Williams & Wilkins
Place of publication England
Publication date 1999-03
ISSN 0268-1315
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Psychiatry
PSYCHIATRY, SCI
glutamate
platelet intracellular calcium response
receptor supersensitivity
D-ASPARTATE RECEPTORS
INTRACELLULAR CALCIUM
AFFECTIVE-DISORDERS
GENERATION
SEROTONIN
MODEL
Summary Hypoglutamatergic function is implicated in the pathogenesis of schizophrenia. The aim of this study was to examine the platelet intracellular calcium response to glutamate using spectroflourometry in 15 schizophrenic patients and 15 matched control individuals as an index of platelet glutamate receptor sensitivity. Patients with schizophrenia had significantly lower baseline intracellular calcium levels than matched control individuals (P = 0.03). The percentage response of the schizophrenic individuals to glutamate stimulation was significantly greater than control individuals (P < 0.001). These data suggest that platelet glutamate receptors may be supersensitive in schizophrenia. Furthermore, the platelet may be a possible peripheral marker of glutamate function in schizophrenia.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, Lippincott, Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071344

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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