Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia. Berk,M, Plein,H and Csizmadia,T 1999, Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia., International Clinical Psychopharmacology, vol. 14, no. 2, pp. 119-122. Attached Files Name Description MIMEType Size Downloads Title Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia. Author(s) Berk,M orcid.org/0000-0002-5554-6946 Plein,H Csizmadia,T Journal name International Clinical Psychopharmacology Volume number 14 Issue number 2 Start page 119 End page 122 Publisher Lippincott, Williams & Wilkins Place of publication England Publication date 1999-03 ISSN 0268-1315 Keyword(s) Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy Psychiatry PSYCHIATRY, SCI glutamate platelet intracellular calcium response receptor supersensitivity D-ASPARTATE RECEPTORS INTRACELLULAR CALCIUM AFFECTIVE-DISORDERS GENERATION SEROTONIN MODEL Summary Hypoglutamatergic function is implicated in the pathogenesis of schizophrenia. The aim of this study was to examine the platelet intracellular calcium response to glutamate using spectroflourometry in 15 schizophrenic patients and 15 matched control individuals as an index of platelet glutamate receptor sensitivity. Patients with schizophrenia had significantly lower baseline intracellular calcium levels than matched control individuals (P = 0.03). The percentage response of the schizophrenic individuals to glutamate stimulation was significantly greater than control individuals (P < 0.001). These data suggest that platelet glutamate receptors may be supersensitive in schizophrenia. Furthermore, the platelet may be a possible peripheral marker of glutamate function in schizophrenia. Language eng Field of Research 0 Not Applicable Socio Economic Objective 0 Not Applicable HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©1999, Lippincott, Williams & Wilkins Persistent URL http://hdl.handle.net/10536/DRO/DU:30071344 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 18 Mar 2015, 10:29:46 EST Thu, 19 Mar 2015, 04:14:47 EST Thu, 19 Mar 2015, 05:16:38 EST Wed, 10 Jun 2015, 11:50:09 EST Wed, 10 Jun 2015, 11:55:59 EST Fri, 09 Oct 2015, 17:08:44 EST Mon, 12 Oct 2015, 15:59:06 EST Filtered Full Citation counts:   Cited 32 times in TR Web of Science Cited 31 times in Scopus Search Google Scholar Access Statistics: 435 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 18 Mar 2015, 10:29:46 EST

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