Olanzapine compared to lithium in mania: a double-blind randomized controlled trial.

Berk,M, Ichim,L and Brook,S 1999, Olanzapine compared to lithium in mania: a double-blind randomized controlled trial., International Clinical Psychopharmacology, vol. 14, no. 6, pp. 339-343.

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Title Olanzapine compared to lithium in mania: a double-blind randomized controlled trial.
Author(s) Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Journal name International Clinical Psychopharmacology
Volume number 14
Issue number 6
Start page 339
End page 343
Publisher Lippincott, Williams & Wilkins
Place of publication England
Publication date 1999-11
ISSN 0268-1315
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Summary Neuroleptics are of established efficacy in mania. Controlled data on the use of olanzapine in mania is however, absent. In this study, 30 patients meeting DSM-IV criteria for mania were randomly allocated to receive either olanzapine or lithium in a 4 week double-blind randomized controlled design. There were no significant outcome differences between the two groups on any of the primary outcome measures, the Brief Psychiatric Rating Scale (lithium 28.2; olanzapine 28.0; P = 0.44); Clinical Global Impression (CGI) improvement scale (lithium 2.75, olanzapine 2.36; P = 0.163) or the Mania Scale (lithium 13.2, olanzapine 10.2; P = 0.315). Olanzapine was however, significantly superior to lithium on the CGI-severity scale at week 4 (lithium 2.83, olanzapine 2.29; P = 0.025). Olanzapine did not differ from lithium in terms of treatment emergent extrapyramidal side-effects as measured by the Simpson-Angus Scale. Olanzapine appears to be at least as effective as lithium in the treatment of mania.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, Lippincott, Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071348

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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