Olanzapine compared to lithium in mania: a double-blind randomized controlled trial.

Berk,M, Ichim,L and Brook,S 1999, Olanzapine compared to lithium in mania: a double-blind randomized controlled trial., International Clinical Psychopharmacology, vol. 14, no. 6, pp. 339-343.

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Title Olanzapine compared to lithium in mania: a double-blind randomized controlled trial.
Author(s) Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Ichim,L
Brook,S
Journal name International Clinical Psychopharmacology
Volume number 14
Issue number 6
Start page 339
End page 343
Publisher Lippincott, Williams & Wilkins
Place of publication England
Publication date 1999-11
ISSN 0268-1315
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Psychiatry
PSYCHIATRY, SCI
olanzapine
mania
SINGLE-BLIND
HALOPERIDOL
SCHIZOPHRENIA
DISORDERS
RISPERIDONE
EFFICACY
SYMPTOMS
Summary Neuroleptics are of established efficacy in mania. Controlled data on the use of olanzapine in mania is however, absent. In this study, 30 patients meeting DSM-IV criteria for mania were randomly allocated to receive either olanzapine or lithium in a 4 week double-blind randomized controlled design. There were no significant outcome differences between the two groups on any of the primary outcome measures, the Brief Psychiatric Rating Scale (lithium 28.2; olanzapine 28.0; P = 0.44); Clinical Global Impression (CGI) improvement scale (lithium 2.75, olanzapine 2.36; P = 0.163) or the Mania Scale (lithium 13.2, olanzapine 10.2; P = 0.315). Olanzapine was however, significantly superior to lithium on the CGI-severity scale at week 4 (lithium 2.83, olanzapine 2.29; P = 0.025). Olanzapine did not differ from lithium in terms of treatment emergent extrapyramidal side-effects as measured by the Simpson-Angus Scale. Olanzapine appears to be at least as effective as lithium in the treatment of mania.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, Lippincott, Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071348

Document type: Journal Article
Collection: School of Medicine
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