The use of metabolomics in the study of metals in biological systems

Jones, Oliver A. H., Dias, Daniel A., Callahan, Damien L., Kouremenos, Konstantinos A., Beale, David J. and Roessner, Ute 2015, The use of metabolomics in the study of metals in biological systems, Metallomics, vol. 7, no. 1, pp. 29-38, doi: 10.1039/c4mt00123k.

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Title The use of metabolomics in the study of metals in biological systems
Author(s) Jones, Oliver A. H.
Dias, Daniel A.
Callahan, Damien L.ORCID iD for Callahan, Damien L.
Kouremenos, Konstantinos A.
Beale, David J.
Roessner, Ute
Journal name Metallomics
Volume number 7
Issue number 1
Start page 29
End page 38
Total pages 10
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2015-01-01
ISSN 1756-5901
Summary Metabolomics may be defined as the comprehensive quantitative and/or qualitative analysis of all metabolites present in a bio-fluid, cell, tissue, or organism. It is essentially the study of biochemical phenotypes (or metabotypes). Metabolic profiles are context dependent, and vary in response to a variety of factors including environment and environmental stimuli, health status, disease and a myriad of other factors; as such, metabolomics has been applied to a wide range of fields and has been increasingly utilised to the study of the roles played by metals in a range of biological systems as well as, encouragingly, in understanding the underlying biochemical mechanisms. The role of metals (and metalloids) in biological organisms is complex and the majority of studies in this area have been performed in plants but the fields of natural product chemistry, human health and even bacterial corrosion of water distribution systems have been investigated using this technique. In this review some of the novel approaches in which the metabolomics toolbox has been used to unravel the roles of metals and metalloids in a range of biological systems are discussed and suggestions made for future research.
Language eng
DOI 10.1039/c4mt00123k
Field of Research 030101 Analytical Spectrometry
060101 Analytical Biochemistry
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Royal Society of Chemistry
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