A neuropsychological study of prefrontal lobe function in the positive and negative subtypes of schizophrenia.

Mattson,DT, Berk,M and Lucas,MD 1997, A neuropsychological study of prefrontal lobe function in the positive and negative subtypes of schizophrenia., The Journal of Genetic Psychology: Research and Theory on Human Development, vol. 158, no. 4, pp. 487-494, doi: 10.1080/00221329709596685.

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Title A neuropsychological study of prefrontal lobe function in the positive and negative subtypes of schizophrenia.
Author(s) Mattson,DT
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Lucas,MD
Journal name The Journal of Genetic Psychology: Research and Theory on Human Development
Volume number 158
Issue number 4
Start page 487
End page 494
Publisher Taylor & Francis (Routledge)
Place of publication United States
Publication date 1997-12
ISSN 0022-1325
Keyword(s) Social Sciences
Psychology, Developmental
Psychology
Psychology, Multidisciplinary
DYSFUNCTION
SYMPTOMS
DEFICITS
CORTEX
PERFORMANCE
CIRCUITS
BEHAVIOR
Summary The symptoms of schizophrenia are frequently divided into positive and negative subtypes. It has been suggested that the negative symptoms are similar to those seen with prefrontal lobe cortical dysfunction. Several neuropsychological investigations of that hypothesis have been carried out, but none have directly compared a negative symptom group with a positive symptom group on the same test battery. In the present study, the Positive and Negative Syndrome Scale (PANSS; Kay, Fiszbein, & Opler, 1987) was used to distinguish two groups of 20 patients with schizophrenia with predominant positive or negative symptoms. A battery of 7 neuropsychological tests considered capable of isolating prefrontal lobe dysfunction was administered. A significant group difference was noted on 6 of the tests; the negative symptom group performed much worse than the positive symptom group. The results of this study support the hypothesis that a relationship exists between the negative symptoms of schizophrenia and prefrontal lobe dysfunction.
Language eng
DOI 10.1080/00221329709596685
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1997, Taylor & Francis (Routledge)
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071406

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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