Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial.

Segal,J, Berk,M and Brook,S 1998, Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial., Clinical Neuropharmacology, vol. 21, no. 3, pp. 176-180.

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Title Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial.
Author(s) Segal,J
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Brook,S
Journal name Clinical Neuropharmacology
Volume number 21
Issue number 3
Start page 176
End page 180
Publisher Lippincott, Williams & Wilkins
Place of publication United States
Publication date 1998-05
ISSN 0362-5664
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Pharmacology & Pharmacy
Neurosciences & Neurology
mania
BIPOLAR AFFECTIVE-DISORDER
SCHIZOAFFECTIVE DISORDER
SCHIZOPHRENIA
ANTIPSYCHOTICS
PSYCHOSIS
EFFICACY
Summary Case reports and studies of other neuroleptics suggest the efficacy of risperidone in the treatment of mania. Forty-five inpatients with DSM-IV mania were studied in a 28-day randomized, controlled, double-blind trial of either 6 mg daily of risperidone, 10 mg daily of haloperidol, or 800 to 1200 mg daily of lithium. The patients in all three groups showed a similar improvement on the total score for all rating scales at day 28 (Brief Psychiatric rating scale; lithium 9.1, haloperidol 4.9, risperidone 6.5, F = 1.01, df = 2, p = 0.37; Mania rating scale; lithium 15.7, haloperidol 10.2, risperidone 12.4, F = 1.07, df = 2, p = 0.35 [analysis of variance]). The Global Assessment of Functioning and Clinical Global Impression data showed a similar pattern of improvement. This study suggests that risperidone is of equivalent efficacy to lithium and haloperidol in the management of acute mania. The extrapyramidal side effects of risperidone and haloperidol were not significantly different.
Language eng
Field of Research 0 Not Applicable
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1998, Lippincott, Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071442

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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