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Nervous control of circulation--the role of gasotransmitters, NO, CO, and H2S.

Olson,KR and Donald,JA 2009, Nervous control of circulation--the role of gasotransmitters, NO, CO, and H2S., Acta Histochem, vol. 111, no. 3, pp. 244-256, doi: 10.1016/j.acthis.2008.11.004.

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Title Nervous control of circulation--the role of gasotransmitters, NO, CO, and H2S.
Author(s) Olson,KR
Donald,JAORCID iD for Donald,JA orcid.org/0000-0001-5930-2642
Journal name Acta Histochem
Volume number 111
Issue number 3
Start page 244
End page 256
Publisher Elsevier
Place of publication Germany
Publication date 2009
ISSN 1618-0372
Keyword(s) Endothelium
Perivascular nerves
Review
Vascular smooth muscle
Vasoconstriction
Vasodilation
Science & Technology
Life Sciences & Biomedicine
Cell Biology
NITRIC-OXIDE SYNTHASE
TROUT ONCORHYNCHUS-MYKISS
HYDROGEN-SULFIDE
CARBON-MONOXIDE
RAINBOW-TROUT
SQUALUS-ACANTHIAS
SMOOTH-MUSCLE
BLOOD-VESSELS
VENTRAL AORTA
DORSAL AORTA
Summary The origins and actions of gaseous signaling molecules, nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H(2)S) in the mammalian cardiovascular system have received considerable attention and it is evident that these three "gasotransmitters" perform a variety of homeostatic functions. The origins, actions and disposition of these gasotransmitters in the piscine vasculature are far from resolved. In most fish examined to date, NO or NO donors are generally in vitro and in vivo vasodilators acting via soluble guanylyl cyclase, although there is evidence for NO-mediated vasoconstriction. Injection of sodium nitroprusside into trout causes hypotension that is attributed to a reduction in systemic resistance. Unlike mammals, NO does not appear to have an endothelial origin in fish blood vessels as an endothelial NO synthase has not identified. However, neural NO synthase is prevalent in perivascular nerves and is the most likely source of NO for cardiovascular control in fish. CO is a vasodilator in lamprey and trout vessels, and it, like NO, appears to exert its action, at least in part, via guanylyl cyclase and potassium channel activation. Inhibition of CO production increases resting tone in trout vessels suggestive of tonic CO activity, but little else is known about the origin or control of CO in the fish vasculature. H(2)S is synthesized by fish vessels and its constrictory, dilatory, or even multi-phasic actions, are both species- and vessel-specific. A small component of H(2)S-mediated basal activity may be endothelial in origin, but to a large extent H(2)S affects vascular smooth muscle directly and the mechanisms are unclear. H(2)S injected into the dorsal aorta of unanesthetized trout often produces oscillations in arterial blood pressure suggestive of H(2)S activity in the central nervous system as well as peripheral vasculature. Collectively, these studies hint at significant involvement of the gasotransmitters in piscine cardiovascular function and hopefully provide a variety of avenues for future research.
Language eng
DOI 10.1016/j.acthis.2008.11.004
Field of Research 060807 Animal Structure and Function
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071573

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