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Improving quantification using curtain flow chromatography columns in the analysis of labile compounds: a study on amino acids.

Kocic,D, Pereira,L, Edge,T, Ritchie,H, Conlan,XA and Shalliker,RA 2014, Improving quantification using curtain flow chromatography columns in the analysis of labile compounds: a study on amino acids., Journal of Chromatography A, vol. 1375, pp. 76-81, doi: 10.1016/j.chroma.2014.11.078.

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Title Improving quantification using curtain flow chromatography columns in the analysis of labile compounds: a study on amino acids.
Author(s) Kocic,D
Pereira,L
Edge,T
Ritchie,H
Conlan,XAORCID iD for Conlan,XA orcid.org/0000-0003-0829-0551
Shalliker,RA
Journal name Journal of Chromatography A
Volume number 1375
Start page 76
End page 81
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014-01
ISSN 1873-3778
Keyword(s) Active flow technology
Amino acids
Curtain flow
HPLC–MS/MS
Labile compounds
Mass spectrometry
HPLC-MS/MS
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Chemistry, Analytical
Biochemistry & Molecular Biology
Chemistry
LIQUID-CHROMATOGRAPHY
SEGMENTED FLOW
THROUGH-PUT
Summary The performance of curtain flow chromatography column technology with MS detection was evaluated for the analysis of labile compounds. The curtain flow column design allows for separations that are faster and/or more sensitive than conventional columns, depending on how exactly the curtain flow column is configured. For example, when mass spectral detection is employed, the curtain flow column can yield separations that are 5-times faster than conventional columns when the curtain flow and the conventional columns have the same internal diameter. Or when the internal diameter of the conventional column is reduced in order to yield the same analytical through-put as the curtain flow column, the sensitivity on the curtain flow column can be as much as 66-fold higher than the conventional column. As a consequence of the higher analytical through-put less standardization is required in the analysis of labile compounds because less sample degradation is apparent. Consequently the sample integrity is preserved yielding data of a higher quality.
Language eng
DOI 10.1016/j.chroma.2014.11.078
Field of Research 030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071581

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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Created: Thu, 19 Mar 2015, 10:24:55 EST

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