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MicroRNA pathways : an emerging role in identification of therapeutic strategies

Vijayarathna,S, Oon,CE, Jothy,SL, Chen,Y, Kanwar,JR and Sasidharan,S 2014, MicroRNA pathways : an emerging role in identification of therapeutic strategies, Current Gene Therapy, vol. 14, no. 2, pp. 112-120.

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Title MicroRNA pathways : an emerging role in identification of therapeutic strategies
Author(s) Vijayarathna,S
Oon,CE
Jothy,SL
Chen,Y
Kanwar,JRORCID iD for Kanwar,JR orcid.org/0000-0003-3728-9568
Sasidharan,S
Journal name Current Gene Therapy
Volume number 14
Issue number 2
Start page 112
End page 120
Total pages 9
Publisher Bentham Science Publishers
Place of publication Bussum, Netherlands
Publication date 2014
ISSN 1875-5631
Keyword(s) Canonical pathways
Circulating miRNAs
MiRNA biogenesis
Non-canonical pathways
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
MESSENGER-RNAS
POSTTRANSCRIPTIONAL REGULATION
INTERCELLULAR COMMUNICATION
BIOGENESIS PATHWAYS
MIRNA
METASTASIS
EXPRESSION
CELLS
EXCHANGE
SPECTRUM
Animals
Cell Nucleus
Gene Regulatory Networks
Humans
MicroRNAs
Signal Transduction
Summary For years researchers have exerted every effort to improve the influential roles of microRNA (miRNA) in regulating genes that direct mammalian cell development and function. In spite of numerous advancements, many facets of miRNA generation remain unresolved due to the perplexing regulatory networks. The biogenesis of miRNA, eminently endures as a mystery as no universal pathway defines or explicates the variegation in the rise of miRNAs. Early evidence in biogenesis ignited specific steps of being omitted or replaced that eventuate in the individual miRNAs of different mechanisms. Understanding the basic foundation concerning how miRNAs are generated and function will help with diagnostic tools and therapeutic strategies. This review encompasses the canonical and the non-canonical pathways involved in miRNA biogenesis, while elucidating how miRNAs regulate genes at the nuclear level and also the mechanism that lies behind circulating miRNAs.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071585

Document type: Journal Article
Collection: School of Medicine
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