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MicroRNAs: biogenesis, roles for carcinogenesis and as potential biomarkers for cancer diagnosis and prognosis

Kavitha,N, Vijayarathna,S, Jothy,SL, Oon,CE, Chen,Y, Kanwar,JR and Sasidharan,S 2014, MicroRNAs: biogenesis, roles for carcinogenesis and as potential biomarkers for cancer diagnosis and prognosis, Asian Pacific journal of cancer prevention, vol. 15, no. 18, pp. 7489-7497, doi: 10.7314/APJCP.2014.15.18.7489.

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Title MicroRNAs: biogenesis, roles for carcinogenesis and as potential biomarkers for cancer diagnosis and prognosis
Author(s) Kavitha,N
Vijayarathna,S
Jothy,SL
Oon,CE
Chen,Y
Kanwar,JR
Sasidharan,S
Journal name Asian Pacific journal of cancer prevention
Volume number 15
Issue number 18
Start page 7489
End page 7497
Publisher Asian Pacific Organization for Cancer Prevention
Place of publication Bangkok, Thailand
Publication date 2014
ISSN 1513-7368
Keyword(s) Cancer
Cell cycle control
miRNA dysregulation
Oncogene
Science & Technology
Life Sciences & Biomedicine
Oncology
LUNG-CANCER
BREAST-CANCER
DNA METHYLATION
GASTRIC-CANCER
SMALL RNAS
EXPRESSION
GENE
TARGET
CELLS
P53
Summary MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current knowledge and concepts concerning the biogenesis of miRNAs, miRNA roles in cancer and their potential as biomarkers for cancer diagnosis and prognosis including the regulation of key cancer-related pathways, such as cell cycle control and miRNA dysregulation. Moreover, microRNA molecules are already receiving the attention of world researchers as therapeutic targets and agents. Therefore, in-depth knowledge of microRNAs has the potential not only to identify their roles in cancer, but also to exploit them as potential biomarkers for cancer diagnosis and identify therapeutic targets for new drug discovery.
Language eng
DOI 10.7314/APJCP.2014.15.18.7489
Field of Research 111202 Cancer Diagnosis
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C3 Non-refereed articles in a professional journal
ERA Research output type X Not reportable
Copyright notice ©2014, Asian Pacific Organization for Cancer Prevention
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071586

Document type: Journal Article
Collection: School of Medicine
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