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Nanocapsules loaded with iron-saturated bovine lactoferrin have antimicrobial therapeutic potential and maintain calcium, zinc and iron metabolism

Gupta,I, Sehgal,R, Kanwar,RK, Punj,V and Kanwar,JR 2014, Nanocapsules loaded with iron-saturated bovine lactoferrin have antimicrobial therapeutic potential and maintain calcium, zinc and iron metabolism, Nanomedicine, pp. 1-26, doi: 10.2217/nnm.14.209.

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Title Nanocapsules loaded with iron-saturated bovine lactoferrin have antimicrobial therapeutic potential and maintain calcium, zinc and iron metabolism
Author(s) Gupta,I
Sehgal,R
Kanwar,RK
Punj,V
Kanwar,JR
Journal name Nanomedicine
Start page 1
End page 26
Total pages 26
Publisher Future Medicine
Place of publication London, United Kingdom
Publication date 2014-12-02
ISSN 1748-6963
Keyword(s) Salmonella typhimurium infected
lactoferrin
miRNA
oral nanodelivery
targeted nanodelivery
Summary Aim: This study aimed to evaluate the potential antimicrobial efficacy of alginate gel-encapsulated ceramic nanocarriers loaded with iron-saturated bovine lactoferrin (Fe-bLf) nanocarriers/nanocapsules (AEC-CP-Fe-bLf NCs). Materials & methods: The antimicrobial activities of non-nanoformulated apo (iron free), Fe-bLf and native forms of Australian bLf against pathogenic Salmonella typhimurium (wild strain) were studied in vitro. The efficacy of AEC-CP-Fe-bLf NCs were checked in vivo using Balb/c mice model. Results: The study revealed that native bLf is more effective in combating infection than the conventional drug ciprofloxacin (0.4 mg/ml). The efficacy of the drug was also revealed in vivo when BALB/c mice that, after being challenged with S. typhimurium (200 μl of 10(8) CFU/ml suspension), were fed orally with a nanoformulated bLf diet and the infection was observed to be eliminated. However, chronic infection developed in the group of infected mice that did not receive any drug treatment, as well as the mice treated with ciprofloxacin. The immune response to bacterial infection and to various drug treatments thereafter was studied in the mice. Conclusion: The study concludes that bLf and nanoformulated Fe-bLf are more effective in the treatment of Salmonella-infected mice than ciprofloxacin.
Language eng
DOI 10.2217/nnm.14.209
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Future Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071589

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 19 Mar 2015, 10:48:05 EST

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