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Nanomedicine based nanoparticles for neurological disorders

Sriramoju,B, Kanwar,RK and Kanwar,JR 2014, Nanomedicine based nanoparticles for neurological disorders, Current medicinal chemistry, vol. 21, no. 36, pp. 4154-4168.

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Title Nanomedicine based nanoparticles for neurological disorders
Author(s) Sriramoju,B
Kanwar,RK
Kanwar,JR
Journal name Current medicinal chemistry
Volume number 21
Issue number 36
Start page 4154
End page 4168
Publisher Bentham Science Publishers
Place of publication Bussum, Netherlands
Publication date 2014
ISSN 1875-533X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Chemistry, Medicinal
Pharmacology & Pharmacy
Blood brain barrier
nanomedicine
neurological disorders
polymeric nanoparticles
targeted therapeutics
BLOOD-BRAIN-BARRIER
IRON-OXIDE NANOPARTICLES
PEG-PLGA NANOPARTICLES
TARGETED DRUG-DELIVERY
CENTRAL-NERVOUS-SYSTEM
HUMAN INSULIN-RECEPTOR
IN-VIVO
NEURODEGENERATIVE DISORDERS
MONOCLONAL-ANTIBODIES
PARKINSONS-DISEASE
Summary Human health is severely hampered by a majority of the neurological disorders such as the brain tumors, degenerative Alzheimer's disease, Parkinson's disease and those involving inflammatory component. Owing to the stringent protection offered by the blood brain barrier, conventional therapeutics gain limited access and therefore, are therapeutically suboptimal. Hence, research has now focused to develop the novel drug delivery systems with a prime motto of maintaining therapeutic drug levels inside the brain, avoiding non-specific tissue distribution. The introduction of nanotechnology has addressed few of these objectives and opened up new avenues for even more improvization. To some extent, nanodelivery systems were successful in crossing the blood brain barrier and accessing the remote areas of the brain. They also have shown tremendous potential in delivering the therapeutic and diagnostic aids following systemic administration. What revolutionised the nano applications is the development of "smart" nanosystems, whose surface is tailor made for the effective theranostic delivery. However, a detailed understanding of the long term nanoformulation toxicities, along with the neuropathology, is the critical future question to be addressed. In this review, a brief introduction of the prominent neurological disorders and detailed applications of nanotechnology are discussed.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071591

Document type: Journal Article
Collection: School of Medicine
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