You are not logged in.
Openly accessible

Molecular imaging of metabolism in cancer metastasis

Pouliot,N and Denoyer,D 2014, Molecular imaging of metabolism in cancer metastasis, Cancer forum, vol. 38, no. 2, pp. 124-128.

Attached Files
Name Description MIMEType Size Downloads
denoyer-molecularimaging-2014.pdf Published version application/pdf 506.22KB 47

Title Molecular imaging of metabolism in cancer metastasis
Author(s) Pouliot,N
Denoyer,DORCID iD for Denoyer,D orcid.org/0000-0001-8932-5116
Journal name Cancer forum
Volume number 38
Issue number 2
Start page 124
End page 128
Total pages 5
Publisher Cancer Council Australia
Place of publication Kogarah, N.S.W.
Publication date 2014-07
ISSN 0311-306X
Summary Cancer progression is characterised by extensive metabolic reprogramming. Renewed enthusiasm in this field has been sparked in part by the realisation that metabolic pathways, oncogenes and tumour suppressors are intimately linked and regulate tumour growth and metastasis through complex reciprocal interactions. The identification of key pathways and enzymes regulating metabolism in cancer cells provides new opportunities for cancer therapy. This has motivated the development of several specific inhibitors targeting metabolic pathways and their therapeutic evaluation in pre-clinical models or in cancer patients. The unravelling of metabolic pathways associated with cancer progression has also highlighted the extensive metabolic heterogeneity that exists between, and within, each cancer type as well as between metastatic sites. The translation of these findings into personalised therapy remains a considerable challenge. To this end, the use of positron emission tomography to non-invasively visualise tumour metabolism is likely to facilitate the implementation of and assessment of new targeted therapies. Here, we briefly review the key metabolic changes associated with cancer progression and discuss recent advances in the field of positron emission tomography for metabolic imaging of cancer and their potential to improve the clinical management of cancer patients.
Language eng
Field of Research 111201 Cancer Cell Biology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Cancer Council Australia
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071623

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 1 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 27 Abstract Views, 47 File Downloads  -  Detailed Statistics
Created: Thu, 19 Mar 2015, 15:10:22 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.