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The evolution of nitric oxide signalling in vertebrate blood vessels

Donald,JA, Forgan,LG and Cameron,MS 2015, The evolution of nitric oxide signalling in vertebrate blood vessels, Journal of comparative physiology B, vol. 185, no. 2, pp. 153-171, doi: 10.1007/s00360-014-0877-1.

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Title The evolution of nitric oxide signalling in vertebrate blood vessels
Author(s) Donald,JAORCID iD for Donald,JA orcid.org/0000-0001-5930-2642
Forgan,LG
Cameron,MS
Journal name Journal of comparative physiology B
Volume number 185
Issue number 2
Start page 153
End page 171
Total pages 19
Publisher Springer
Place of publication Berlin, Germany
Publication date 2015-02
ISSN 1432-136X
Keyword(s) Endothelium
Nitric oxide
Nitric oxide synthase
Nitrite
Vasodilation
Vertebrate
Science & Technology
Life Sciences & Biomedicine
Physiology
Zoology
VASCULAR SMOOTH-MUSCLE
TOAD BUFO-MARINUS
ENDOTHELIUM-DEPENDENT RELAXATIONS
TURTLE TRACHEMYS-SCRIPTA
MYKISS CORONARY SYSTEM
RAINBOW-TROUT
ONCORHYNCHUS-MYKISS
HYPERPOLARIZING FACTOR
ESTUARINE CROCODILE
CROCODYLUS-POROSUS
Summary Nitric oxide is one of the most important signalling molecules involved in the regulation of physiological function. It first came to prominence when it was discovered that the vascular endothelium of mammals synthesises and releases nitric oxide (NO) to mediate a potent vasodilation. Subsequently, it was shown that NO is synthesised in the endothelium by a specific isoform of nitric oxide synthase (NOS) called NOS3. Following this discovery, it was assumed that an endothelial NO/NOS3 system would be present in all vertebrate blood vessels. This review will discuss the latest genomic, anatomical and physiological evidence which demonstrates that an endothelial NO/NOS3 signalling is not ubiquitous in non-mammalian vertebrates, and that there have been key evolutionary steps that have led to the endothelial NO signalling system being a regulatory system found only in reptiles, birds and mammals. Furthermore, the emerging role of nitrite as an endocrine source of NO for vascular regulation is discussed.
Language eng
DOI 10.1007/s00360-014-0877-1
Field of Research 060807 Animal Structure and Function
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Springer Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071647

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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Created: Fri, 20 Mar 2015, 12:01:08 EST

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