Aptamer-mediated cancer gene therapy

Xiang,D, Shigdar,S, Qiao,G, Zhou,SF, Li,Y, Wei,MQ, Qiao,L, Shamaileh,HA, Zhu,Y, Zheng,C, Pu,C and Duan,W 2015, Aptamer-mediated cancer gene therapy, Current Gene Therapy, vol. 15, no. 2, pp. 109-119.

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Title Aptamer-mediated cancer gene therapy
Author(s) Xiang,D
Shigdar,SORCID iD for Shigdar,S orcid.org/0000-0001-8084-8447
Duan,WORCID iD for Duan,W orcid.org/0000-0001-5782-9184
Journal name Current Gene Therapy
Volume number 15
Issue number 2
Start page 109
End page 119
Total pages 11
Publisher Bentham Science Publishers Ltd
Place of publication Bussum, Netherlands
Publication date 2015
ISSN 1875-5631
Summary Cancer as a genetic disorder is one of the leading causes of death worldwide. Conventional anticancer options such as chemo- and/or radio-therapy have their own drawbacks and could not provide a cure in most cases at present. More effective therapeutic strategies with less side effects are urgently needed. Aptamers, also known as chemical antibodies, are single strand DNA or RNA molecules that can bind to their target molecules with high affinity and specificity. Such site-specific binding ability of aptamers facilitates the delivery and interaction of exogenous nucleic acids with diseased genes. Thus, aptamer-guided gene therapy has emerged as a promising anticancer strategy in addition to the classic treatment regimen. Aptamers can directly deliver anti-cancer nucleic acids, e.g. small interfering RNA, micro RNA, antimicroRNA and small hairpin RNA, to cancer cells or function as a targeting ligand to guide nanoparticles containing therapeutic nucleic acids. This review focuses on recent progress in aptamer-mediated gene therapy for the treatment of hepatocellular carcinoma and other types of cancers, shedding light on the potential of this novel approach of targeted cancer gene therapy.
Language eng
Field of Research 111203 Cancer Genetics
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Bentham Science Publishers Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071749

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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