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Nerve guidance conduits from aligned nanofibers: improvement of nerve regeneration through longitudinal nanogrooves on a fiber surface

Huang, Chen, Ouyang, Yuanming, Niu, Haitao, He, Nanfei, Ke, Qinfei, Jin, Xiangyu, Li, Dawei, Fang, Jun, Liu, Wanjun, Fan, Cunyi and Lin, Tong 2015, Nerve guidance conduits from aligned nanofibers: improvement of nerve regeneration through longitudinal nanogrooves on a fiber surface, ACS applied materials & interfaces, vol. 7, no. 13, pp. 7189-7196, doi: 10.1021/am509227t.

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Title Nerve guidance conduits from aligned nanofibers: improvement of nerve regeneration through longitudinal nanogrooves on a fiber surface
Author(s) Huang, Chen
Ouyang, Yuanming
Niu, HaitaoORCID iD for Niu, Haitao orcid.org/0000-0002-8442-7444
He, Nanfei
Ke, Qinfei
Jin, Xiangyu
Li, Dawei
Fang, Jun
Liu, Wanjun
Fan, Cunyi
Lin, TongORCID iD for Lin, Tong orcid.org/0000-0002-1003-0671
Journal name ACS applied materials & interfaces
Volume number 7
Issue number 13
Start page 7189
End page 7196
Total pages 8
Publisher American Chemical Society
Place of publication Washington, DC.
Publication date 2015
ISSN 1944-8252
Keyword(s) electrospinning
groove
nanofibers
nerve guidance conduit
nerve regeneration
tissue engineering
Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
CELLULOSE NANOCRYSTALS
SCIATIC-NERVE
STEM-CELLS
TISSUE
WATER
ADHESION
FABRICATION
CONDUCTION
STRATEGIES
SCAFFOLDS
Summary A novel fibrous conduit consisting of well-aligned nanofibers with longitudinal nanogrooves on the fiber surface was prepared by electrospinning and was subjected to an in vivo nerve regeneration study on rats using a sciatic nerve injury model. For comparison, a fibrous conduit having a similar fiber alignment structure without surface groove and an autograft were also conducted in the same test. The electrophysiological, walking track, gastrocnemius muscle, triple-immunofluorescence, and immunohistological analyses indicated that grooved fibers effectively improved sciatic nerve regeneration. This is mainly attributed to the highly ordered secondary structure formed by surface grooves and an increase in the specific surface area. Fibrous conduits made of longitudinally aligned nanofibers with longitudinal nanogrooves on the fiber surface may offer a new nerve guidance conduit for peripheral nerve repair and regeneration.
Language eng
DOI 10.1021/am509227t
Field of Research 090301 Biomaterials
091205 Functional Materials
100707 Nanomanufacturing
Socio Economic Objective 860406 Synthetic Fibres
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, American Chemical Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071929

Document type: Journal Article
Collection: Institute for Frontier Materials
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Created: Fri, 21 Aug 2015, 14:13:53 EST

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