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Functionalization of hollow mesoporous silica nanoparticles for improved 5-fu loading

She, Xiaodong, Chen, Lijue, Li, Chengpeng, He, Canzhong, He, Li and Kong, Lingxue 2015, Functionalization of hollow mesoporous silica nanoparticles for improved 5-fu loading, Journal of nanomaterials, vol. 2015, pp. 1-9, doi: 10.1155/2015/872035.

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Title Functionalization of hollow mesoporous silica nanoparticles for improved 5-fu loading
Author(s) She, Xiaodong
Chen, Lijue
Li, Chengpeng
He, Canzhong
He, Li
Kong, LingxueORCID iD for Kong, Lingxue orcid.org/0000-0001-6219-3897
Journal name Journal of nanomaterials
Volume number 2015
Start page 1
End page 9
Publisher Hindawi Publishing Corporation
Place of publication New York, NY
Publication date 2015
ISSN 1687-4110
1687-4129
Summary  Hollow mesoporous silica nanoparticles were successfully fabricated and functionalized with appropriate silanes. After modifications, amine, carboxyl, cyano, and methyl groups were grafted onto the nanoparticles and all functionalized hollow mesoporous silica nanoparticles maintained a spherical and hollow structure with a mean diameter of ~120 nm and a shell thickness of ~10 nm. The loading capacity of the hollow mesoporous silica nanoaprticles to the anticancer drug, 5-fluorouracil, can be controlled via precise functionalization. The presence of amine groups on the surface of nanoparticles resulted in the highest loading capacity of 28.89%, due to the amine functionalized nanoparticles having a similar hydrophilicity but reverse charge to the drug. In addition, the change in pH leads to the variation of the intensity of electrostatic force between nanoparticles and the drug, which finally affects the loading capacity of amine functionalized hollow mesoporous silica nanoparticles to some extent. Higher drug loading was observed at pH of 7.4 and 8.5 as 5-fluorouracil becomes more deprotonated in alkaline conditions. The improved drug loading capacity by amine functionalized hollow mesoporous silica nanoparticles has demonstrated that they can become potential intracellular 5-fluorouracil delivery vehicles for cancers.
Language eng
DOI 10.1155/2015/872035
Field of Research 090406 Powder and Particle Technology
Socio Economic Objective 860803 Human Pharmaceutical Treatments (e.g. Antibiotics)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Hindawi Publishing Corporation
Persistent URL http://hdl.handle.net/10536/DRO/DU:30071931

Document type: Journal Article
Collections: Institute for Frontier Materials
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Created: Tue, 31 Mar 2015, 15:03:15 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.