FRAX (Aus) and falls risk: Association in men and women

Holloway,KL, Kotowicz,MA, Lane,SE, Brennan,SL and Pasco,JA 2015, FRAX (Aus) and falls risk: Association in men and women, Bone, vol. 76, pp. 1-4, doi: 10.1016/j.bone.2015.03.004.

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Title FRAX (Aus) and falls risk: Association in men and women
Author(s) Holloway,KLORCID iD for Holloway,KL
Kotowicz,MAORCID iD for Kotowicz,MA
Brennan,SLORCID iD for Brennan,SL
Pasco,JAORCID iD for Pasco,JA
Journal name Bone
Volume number 76
Start page 1
End page 4
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-07
ISSN 8756-3282
Keyword(s) Elderly Falls Screening Test
Falls risk
Fracture prediction
FRAX score
Summary Purpose: The WHO fracture risk prediction tool (FRAX®) utilises clinical risk factors to estimate the probability of fracture over a 10-year period. Although falls increase fracture risk, they have not been incorporated into FRAX. It is currently unclear if FRAX captures falls risk and whether addition of falls would improve fracture prediction. We aimed to investigate the association of falls risk and Australian-specific FRAX. Methods: Clinical risk factors were documented for 735 men and 602 women (age 40-90. yr) assessed at follow-up (2006-2010 and 2000-2003, respectively) of the Geelong Osteoporosis Study. FRAX scores with and without BMD were calculated. A falls risk score was determined at the time of BMD assessment and self-reported incident falls were documented from questionnaires returned one year later. Multivariable analyses were performed to determine: (i) cross-sectional association between FRAX scores and falls risk score (Elderly Falls Screening Test, EFST) and (ii) prospective relationship between FRAX and time to a fall. Results: There was an association between FRAX (hip with BMD) and EFST scores (. β=. 0.07, p<. 0.001). After adjustment for sex and age, the relationship became non-significant (. β=. 0.00, p=. 0.79). The risk of incident falls increased with increasing FRAX (hip with BMD) score (unadjusted HR 1.04, 95% CI 1.02, 1.07). After adjustment for age and sex, the relationship became non-significant (1.01, 95% CI 0.97, 1.05). Conclusions: There is a weak positive correlation between FRAX and falls risk score, that is likely explained by the inclusion of age and sex in the FRAX model. These data suggest that FRAX score may not be a robust surrogate for falls risk and that inclusion of falls in fracture risk assessment should be further explored.
Language eng
DOI 10.1016/j.bone.2015.03.004
Field of Research 110314 Orthopaedics
Socio Economic Objective 920502 Health Related to Ageing
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Elsevier
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Document type: Journal Article
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School of Medicine
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