Is there an interaction between socioeconomic status and FRAX 10-year fracture probability determined with and without bone density measures? Data from the Geelong Osteoporosis Study of female cohort.

Brennan,SL, Quirk,SE, Hosking,SM, Kotowicz,MA, Holloway,KL, Moloney,DJ, Dobbins,AG and Pasco,JA 2015, Is there an interaction between socioeconomic status and FRAX 10-year fracture probability determined with and without bone density measures? Data from the Geelong Osteoporosis Study of female cohort., Calcified Tissue International, vol. 96, no. 2, pp. 138-144, doi: 10.1007/s00223-014-9946-4.

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Title Is there an interaction between socioeconomic status and FRAX 10-year fracture probability determined with and without bone density measures? Data from the Geelong Osteoporosis Study of female cohort.
Author(s) Brennan,SL
Quirk,SE
Hosking,SM
Kotowicz,MAORCID iD for Kotowicz,MA orcid.org/0000-0002-8094-1411
Holloway,KLORCID iD for Holloway,KL orcid.org/0000-0001-5064-2990
Moloney,DJ
Dobbins,AG
Pasco,JAORCID iD for Pasco,JA orcid.org/0000-0002-8968-4714
Journal name Calcified Tissue International
Volume number 96
Issue number 2
Start page 138
End page 144
Publisher Springer
Place of publication United States
Publication date 2015-02
ISSN 1432-0827
Keyword(s) Australia
Bone mineral density
FRAX
Social disadvantage
Women
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
AUSTRALIAN POPULATION
MINERAL DENSITY
HEALTH LITERACY
RISK
PREDICTION
BMD
Summary FRAX(©) evaluates 10-year fracture probabilities and can be calculated with and without bone mineral density (BMD). Low socioeconomic status (SES) may affect BMD, and is associated with increased fracture risk. Clinical risk factors differ by SES; however, it is unknown whether aninteraction exists between SES and FRAX determined with and without the BMD. From the Geelong Osteoporosis Study, we drew 819 females aged ≥50 years. Clinical data were collected during 1993-1997. SES was determined by cross-referencing residential addresses with Australian Bureau of Statistics census data and categorized in quintiles. BMD was measured by dual energy X-ray absorptiometry at the same time as other clinical data were collected. Ten-year fracture probabilities were calculated using FRAX (Australia). Using multivariable regression analyses, we examined whether interactions existed between SES and 10-year probability for hip and any major osteoporotic fracture (MOF) defined by use of FRAX with and without BMD. We observed a trend for a SES * FRAX(no-BMD) interaction term for 10-year hip fracture probability (p = 0.09); however, not for MOF (p = 0.42). In women without prior fracture (n = 518), we observed a significant SES * FRAX(no-BMD) interaction term for hip fracture (p = 0.03) and MOF (p = 0.04). SES does not appear to have an interaction with 10-year fracture probabilities determined by FRAX with and without BMD in women with previous fracture; however, it does appear to exist for those without previous fracture.
Language eng
DOI 10.1007/s00223-014-9946-4
Field of Research 110314 Orthopaedics
Socio Economic Objective 920502 Health Related to Ageing
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Springer Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072094

Document type: Journal Article
Collection: School of Medicine
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