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Metabolism and functions of copper in brain

Scheiber,IF, Mercer,JF and Dringen,R 2014, Metabolism and functions of copper in brain, Progress in neurobiology, vol. 116, pp. 33-57, doi: 10.1016/j.pneurobio.2014.01.002.

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Title Metabolism and functions of copper in brain
Author(s) Scheiber,IF
Mercer,JF
Dringen,R
Journal name Progress in neurobiology
Volume number 116
Start page 33
End page 57
Total pages 25
Publisher Elsevier
Place of publication London, Eng.
Publication date 2014-05
ISSN 1873-5118
Keyword(s) Astrocytes
Brain
Copper
Neurodegeneration
Transport
Animals
Homeostasis
Humans
Neurodegenerative Diseases
Neurons
Summary Copper is an important trace element that is required for essential enzymes. However, due to its redox activity, copper can also lead to the generation of toxic reactive oxygen species. Therefore, cellular uptake, storage as well as export of copper have to be tightly regulated in order to guarantee sufficient copper supply for the synthesis of copper-containing enzymes but also to prevent copper-induced oxidative stress. In brain, copper is of importance for normal development. In addition, both copper deficiency as well as excess of copper can seriously affect brain functions. Therefore, this organ possesses ample mechanisms to regulate its copper metabolism. In brain, astrocytes are considered as important regulators of copper homeostasis. Impairments of homeostatic mechanisms in brain copper metabolism have been associated with neurodegeneration in human disorders such as Menkes disease, Wilson's disease and Alzheimer's disease. This review article will summarize the biological functions of copper in the brain and will describe the current knowledge on the mechanisms involved in copper transport, storage and export of brain cells. The role of copper in diseases that have been connected with disturbances in brain copper homeostasis will also be discussed.
Language eng
DOI 10.1016/j.pneurobio.2014.01.002
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072118

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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