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Regulation of the STARS signaling pathway in response to endurance and resistance exercise and training

Lamon, Severine, Wallace, Marita A., Stefanetti, Renae J., Rahbek, Stine K., Vendelbo, Mikkel H., Russell, Aaron P. and Vissing, Kristian 2013, Regulation of the STARS signaling pathway in response to endurance and resistance exercise and training, Pfluegers Archiv: European journal of physiology, vol. 465, no. 9, pp. 1317-1325, doi: 10.1007/s00424-013-1265-5.

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Title Regulation of the STARS signaling pathway in response to endurance and resistance exercise and training
Author(s) Lamon, SeverineORCID iD for Lamon, Severine orcid.org/0000-0002-3271-6551
Wallace, Marita A.
Stefanetti, Renae J.
Rahbek, Stine K.
Vendelbo, Mikkel H.
Russell, Aaron P.ORCID iD for Russell, Aaron P. orcid.org/0000-0002-7323-9501
Vissing, Kristian
Journal name Pfluegers Archiv: European journal of physiology
Volume number 465
Issue number 9
Start page 1317
End page 1325
Total pages 9
Publisher Springer
Place of publication Berlin, Germany
Publication date 2013-09
ISSN 1432-2013
Keyword(s) ABRA
MS1
Skeletal muscle
STARS
Science & Technology
Life Sciences & Biomedicine
Physiology
HUMAN SKELETAL-MUSCLE
PHYSICAL-EXERCISE
ACTIN DYNAMICS
GENE
TRANSCRIPTION
HYPERTROPHY
EXPRESSION
ACTIVATOR
THERAPY
ATROPHY
Summary The striated muscle activator of Rho signaling (STARS) protein and members of its downstream signaling pathway, including myocardin-related transcription factor-A (MRTF-A) and SRF, are increased in response to prolonged resistance exercise training but also following a single bout of endurance cycling. The aim of the present study was to measure and compare the regulation of STARS, MRTF-A and SRF mRNA and protein following 10 weeks of endurance training (ET) versus resistance training (RT), as well as before and following a single bout of endurance (EE) versus resistance exercise (RE). Following prolonged training, STARS, MRTF-A and SRF mRNA levels were all increased by similar magnitude, irrespective of training type. In the training-habituated state, STARS mRNA increased following a single-bout RE when measured 2.5 and 5 h post-exercise and had returned to resting level by 22 h following exercise. MRTF-A and SRF mRNA levels were decreased by 2.5, 5, and 22 h following a single bout of RE and EE exercise when compared to their respective basal levels, with no significant difference seen between the groups at any of the time points. No changes in protein levels were observed following the two modes of exercise training or a single bout of exercise. This study demonstrates that the stress signals elicited by ET and RT result in a comparable regulation of members of the STARS pathway. In contrast, a single bout of EE and RE, performed in the trained state, elicit different responses. These observations suggest that in the trained state, the acute regulation of the STARS pathway following EE or RE may be responsible for exercise-specific muscle adaptations.
Language eng
DOI 10.1007/s00424-013-1265-5
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072215

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