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Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells

Cho, Yoshitake, Hazen, Bethany C, Russell, Aaron P and Kralli, Anastasia 2013, Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells, Journal of biological chemistry, vol. 288, no. 35, pp. 25207-25218, doi: 10.1074/jbc.M113.489674.

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Title Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells
Author(s) Cho, Yoshitake
Hazen, Bethany C
Russell, Aaron PORCID iD for Russell, Aaron P orcid.org/0000-0002-7323-9501
Kralli, Anastasia
Journal name Journal of biological chemistry
Volume number 288
Issue number 35
Start page 25207
End page 25218
Total pages 12
Publisher American Society for Biochemistry and Molecular Biology
Place of publication Bethesda, Md.
Publication date 2013-08-30
ISSN 1083-351X
Keyword(s) Bioenergetics
Energy Metabolism
Estrogen-related Receptor
Mitochondrial Biogenesis
Nuclear Receptors
PGC-1α
Skeletal Muscle
Transcription Regulation
Aging
Animals
Base Sequence
Cell Line
Gene Silencing
Humans
Lipid Metabolism
Mice
Molecular Sequence Data
Muscle Contraction
Muscle Proteins
Muscular Atrophy
Muscular Diseases
Myoblasts, Skeletal
Organ Specificity
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Transcription Factors
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
AMYOTROPHIC-LATERAL-SCLEROSIS
ALPHA ERR-ALPHA
NUCLEAR RECEPTOR
GENE-EXPRESSION
FIBER-TYPE
TRANSCRIPTIONAL CONTROL
ENERGY-METABOLISM
PGC-1 COACTIVATORS
CREATINE-KINASE
Summary Mitochondrial oxidative metabolism and energy transduction pathways are critical for skeletal and cardiac muscle function. The expression of genes important for mitochondrial biogenesis and oxidative metabolism are under the control of members of the peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) family of transcriptional coactivators and the estrogen-related receptor (ERR) subfamily of nuclear receptors. Perturbations in PGC-1 and/or ERR activities have been associated with alterations in capacity for endurance exercise, rates of muscle atrophy, and cardiac function. The mechanism(s) by which PGC-1 and ERR proteins regulate muscle-specific transcriptional programs is not fully understood. We show here that PGC-1α and ERRs induce the expression of a so far uncharacterized muscle-specific protein, PGC-1- and ERR-induced regulator in muscle 1 (Perm1), which regulates the expression of selective PGC-1/ERR target genes. Perm1 is required for the basal as well as PGC-1α-enhanced expression of genes with roles in glucose and lipid metabolism, energy transfer, and contractile function. Silencing of Perm1 in cultured myotubes compromises respiratory capacity and diminishes PGC-1α-induced mitochondrial biogenesis. Our findings support a role for Perm1 acting downstream of PGC-1α and ERRs to regulate muscle-specific pathways important for energy metabolism and contractile function. Elucidating the function of Perm1 may enable novel approaches for the treatment of disorders with compromised skeletal muscle bioenergetics, such as mitochondrial myopathies and age-related/disease-associated muscle atrophies.
Language eng
DOI 10.1074/jbc.M113.489674
Field of Research 111601 Cell Physiology
06 Biological Sciences
11 Medical And Health Sciences
03 Chemical Sciences
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, The American Society for Biochemistry and Molecular Biology, Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072216

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