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MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease

Zacharewicz, Evelyn, Lamon, Severine and Russell, Aaron P. 2013, MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease, Frontiers in physiology, vol. 4, Article Number : 266, pp. 1-11, doi: 10.3389/fphys.2013.00266.

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Title MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease
Author(s) Zacharewicz, Evelyn
Lamon, SeverineORCID iD for Lamon, Severine orcid.org/0000-0002-3271-6551
Russell, Aaron P.ORCID iD for Russell, Aaron P. orcid.org/0000-0002-7323-9501
Journal name Frontiers in physiology
Volume number 4
Season Article Number : 266
Start page 1
End page 11
Total pages 11
Publisher Frontiers
Place of publication Lausanne, Switzerland
Publication date 2013
ISSN 1664-042X
Keyword(s) ageing
disease
exercise
miRNA
skeletal muscle
Science & Technology
Life Sciences & Biomedicine
Physiology
DUCHENNE MUSCULAR-DYSTROPHY
AMYOTROPHIC-LATERAL-SCLEROSIS
SERUM RESPONSE FACTOR
RESISTANCE EXERCISE
PROTEIN-SYNTHESIS
ENDURANCE EXERCISE
STEM-CELLS
CAENORHABDITIS-ELEGANS
CIRCULATING MICRORNAS
MESSENGER-RNA
Summary Skeletal muscle makes up approximately 40% of the total body mass, providing structural support and enabling the body to maintain posture, to control motor movements and to store energy. It therefore plays a vital role in whole body metabolism. Skeletal muscle displays remarkable plasticity and is able to alter its size, structure and function in response to various stimuli; an essential quality for healthy living across the lifespan. Exercise is an important stimulator of extracellular and intracellular stress signals that promote positive adaptations in skeletal muscle. These adaptations are controlled by changes in gene transcription and protein translation, with many of these molecules identified as potential therapeutic targets to pharmacologically improve muscle quality in patient groups too ill to exercise. MicroRNAs (miRNAs) are recently identified regulators of numerous gene networks and pathways and mainly exert their effect by binding to their target messenger RNAs (mRNAs), resulting in mRNA degradation or preventing protein translation. The role of exercise as a regulatory stimulus of skeletal muscle miRNAs is now starting to be investigated. This review highlights our current understanding of the regulation of skeletal muscle miRNAs with exercise and disease as well as how they may control skeletal muscle health.
Language eng
DOI 10.3389/fphys.2013.00266
Field of Research 110602 Exercise Physiology
111699 Medical Physiology not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Frontiers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072220

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.