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The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?

Lamon, Severine and Russell, Aaron P. 2013, The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?, Frontiers in physiology, vol. 4, Article Number : 176, pp. 1-9, doi: 10.3389/fphys.2013.00176.

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Title The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?
Author(s) Lamon, SeverineORCID iD for Lamon, Severine orcid.org/0000-0002-3271-6551
Russell, Aaron P.ORCID iD for Russell, Aaron P. orcid.org/0000-0002-7323-9501
Journal name Frontiers in physiology
Volume number 4
Season Article Number : 176
Start page 1
End page 9
Total pages 9
Publisher Frontiers
Place of publication Lausanne, Switzerland
Publication date 2013
ISSN 1664-042X
Keyword(s) cytokines
erythropoietin
erythropoietin receptor
signaling
skeletal muscle
Science & Technology
Life Sciences & Biomedicine
Physiology
RECOMBINANT-HUMAN-ERYTHROPOIETIN
TYROSINE PHOSPHORYLATION
EXERCISE PERFORMANCE
INDUCED APOPTOSIS
ERYTHROID-CELLS
TRANSGENIC MICE
DEFICIENT MICE
BETA-SUBUNIT
DNA-BINDING
CROSS-TALK
Summary Erythropoietin (EPO) primarily activates erythroid cell proliferation and growth and is active in several types of non-hematopoietic cells via its interaction with the EPO-receptor (EPO-R). This review focuses on the role of EPO in skeletal muscle. The EPO-R is expressed in skeletal muscle cells and EPO may promote myoblast differentiation and survival via the activation of the same signaling cascades as in hematopoietic cells, such as STAT5, MAPK and Akt. Inconsistent results exist with respect to the detection of the EPO-R mRNA and protein in muscle cells, tissue and across species and the use of non-specific EPO-R antibodies contributes to this problem. Additionally, the inability to reproducibly detect an activation of the known EPO-induced signaling pathways in skeletal muscle questions the functionality of the EPO-R in muscle in vivo. These equivocal findings make it difficult to distinguish between a direct effect of EPO on skeletal muscle, via the activation of its receptor, and an indirect effect resulting from a better oxygen supply to the muscle. Consequently, the precise role of EPO in skeletal muscle and its regulatory mechanism/s remain to be elucidated. Further studies are required to comprehensively establish the importance of EPO and its function in skeletal muscle health.
Language eng
DOI 10.3389/fphys.2013.00176
Field of Research 111699 Medical Physiology not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Frontiers
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072221

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.