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Lipid merging, protrusion and vesicle release triggered by shrinking/swelling of poly(N-isopropylacrylamide) microgel particles

Dou,Y, Li,J, Yuan,B and Yang,K 2014, Lipid merging, protrusion and vesicle release triggered by shrinking/swelling of poly(N-isopropylacrylamide) microgel particles, Applied surface science, vol. 296, pp. 95-99, doi: 10.1016/j.apsusc.2014.01.050.

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Title Lipid merging, protrusion and vesicle release triggered by shrinking/swelling of poly(N-isopropylacrylamide) microgel particles
Author(s) Dou,Y
Li,JORCID iD for Li,J orcid.org/0000-0003-0709-2246
Yuan,B
Yang,K
Journal name Applied surface science
Volume number 296
Start page 95
End page 99
Total pages 5
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014
ISSN 0169-4332
Keyword(s) Controlled release
Lipid merging
pNIPAM particle
Transformation
Summary Cell membrane changes its morphology during many physiological processes with the assistance of a solid support, such as the cytoskeleton, under an environmental stimulus. Here, a novel type of stimuli-responsive lipogel was fabricated, mimicking the changes of cell membrane. The lipogel was prepared from poly(N-isopropylacrylamide) (pNIPAM) microgel particle and phospholipid by a solvent-exchange method. The temperature dependent volume phase transition of pNIPAM triggers reversible transformation of the lipogel between a lipid vesicle-coated sun-like structure and a contracted hybrid sphere, through lipid merging and protrusion processes, respectively. By contrast, the salt induced pNIPAM phase transition leads to an irreversible vesicle release behaviour. The lipogel creates a unique platform for studying cell membrane behaviour and provides promising candidates in drug delivery and controlled release applications. © 2014 Elsevier B.V. All rights reserved.
Language eng
DOI 10.1016/j.apsusc.2014.01.050
Field of Research 091205 Functional Materials
020405 Soft Condensed Matter
090301 Biomaterials
Socio Economic Objective 970102 Expanding Knowledge in the Physical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072281

Document type: Journal Article
Collection: Institute for Frontier Materials
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