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ETV6 (TEL1) in blood cell development and malignancy

Rasighaemi,P, Liongue,C and Ward,AC 2014, ETV6 (TEL1) in blood cell development and malignancy, Journal of blood disorders, vol. 1, no. 3, pp. 1-7.

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Title ETV6 (TEL1) in blood cell development and malignancy
Author(s) Rasighaemi,P
Liongue,C
Ward,ACORCID iD for Ward,AC orcid.org/0000-0001-7945-7975
Journal name Journal of blood disorders
Volume number 1
Issue number 3
Start page 1
End page 7
Publisher Austin Publishing Group
Place of publication Monroe Township, NJ
Publication date 2014-10-27
Keyword(s) ETV6
TEL1
ETS
Hematopoiesis
Leukemia
Summary  The ETV6 (TEL1) gene encodes a member of the ETS family of transcriptional regulators. It represents one of the most frequently disrupted genes in haematological malignancies, with over 50 different translocations described. Moreover, deletion, silencing or truncating mutations have also been reported, suggesting a potential tumor suppressor function. Recent studies have shown that ETV6 plays a broad and complex role in early hematopoiesis, impacting on the development of multiple lineages, providing new insights into how its perturbation contributes to disease.
Language eng
Field of Research 110202 Haematology
111206 Haematological Tumours
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Austin Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072293

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.