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Reduced mu suppression and altered motor resonance in euthymic bipolar disorder: evidence for a dysfunctional mirror system?

Andrews, Sophie C., Enticott, Peter G., Hoy, Kate E., Thomson, Richard H. and Fitzgerald, Paul B. 2016, Reduced mu suppression and altered motor resonance in euthymic bipolar disorder: evidence for a dysfunctional mirror system?, Social neuroscience, vol. 11, no. 1, pp. 60-71, doi: 10.1080/17470919.2015.1029140.

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Title Reduced mu suppression and altered motor resonance in euthymic bipolar disorder: evidence for a dysfunctional mirror system?
Author(s) Andrews, Sophie C.
Enticott, Peter G.
Hoy, Kate E.
Thomson, Richard H.
Fitzgerald, Paul B.
Journal name Social neuroscience
Volume number 11
Issue number 1
Start page 60
End page 71
Total pages 12
Publisher Taylor & Francis
Place of publication London, Eng.
Publication date 2016
ISSN 1747-0919
1747-0927
Keyword(s) Electroencephalogram
Mirror neurons
Social cognition
Theory of mind
Transcranial magnetic stimulation
Summary Social cognitive difficulties are common in the acute phase of bipolar disorder and, to a lesser extent, during the euthymic stage, and imaging studies of social cognition in euthymic bipolar disorder have implicated mirror system brain regions. This study aimed to use a novel multimodal approach (i.e., including both transcranial magnetic stimulation (TMS) and electroencephalogram (EEG)) to investigate mirror systems in bipolar disorder. Fifteen individuals with euthymic bipolar disorder and 16 healthy controls participated in this study. Single-pulse TMS was applied to the optimal site in the primary motor cortex (M1), which stimulates the muscle of interest during the observation of hand movements (goal-directed or interacting) designed to elicit mirror system activity. Single EEG electrodes (C3, CZ, C4) recorded mu rhythm modulation concurrently. Results revealed that the patient group showed significantly less mu suppression compared to healthy controls. Surprisingly, motor resonance was not significantly different overall between groups; however, bipolar disorder participants showed a pattern of reduced reactivity on some conditions. Although preliminary, this study indicates a potential mirror system deficit in euthymic bipolar disorder, which may contribute to the pathophysiology of the disorder.
Language eng
DOI 10.1080/17470919.2015.1029140
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
170106 Health, Clinical and Counselling Psychology
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Taylor & Francis
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072342

Document type: Journal Article
Collection: School of Psychology
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