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Reproducibility of aortic intima-media thickness in infants using edge-detection software and manual caliper measurements

McCloskey,K, Ponsonby,AL, Carlin,JB, Jachno,K, Cheung,M, Skilton,MR, Koleff,J, Vuillermin,P and Burgner,D 2014, Reproducibility of aortic intima-media thickness in infants using edge-detection software and manual caliper measurements, Cardiovasc ultrasound, vol. 12, no. 1, pp. 1-8, doi: 10.1186/1476-7120-12-18.

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Title Reproducibility of aortic intima-media thickness in infants using edge-detection software and manual caliper measurements
Author(s) McCloskey,K
Ponsonby,AL
Carlin,JB
Jachno,K
Cheung,M
Skilton,MR
Koleff,J
Vuillermin,P
Burgner,D
Journal name Cardiovasc ultrasound
Volume number 12
Issue number 1
Start page 1
End page 8
Publisher BioMed Central
Place of publication London, England
Publication date 2014-06
ISSN 1476-7120
Keyword(s) Barwon Infant Study investigator group
Aortic intima-media thickness
Edge-detection software
Fetal origins of disease
Newborn
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
INTRAUTERINE GROWTH RESTRICTION
MACROSOMIC NEWBORNS
WALL THICKNESS
LIPID PROFILE
YOUNG-ADULTS
RISK-FACTORS
CHILDREN
ULTRASOUND
MARKER
Summary Background: Aortic intima-media thickness measured by transabdominal ultrasound (aIMT) is an intermediate phenotype of cardiovascular risk. We aimed to (1) investigate the reproducibility of aIMT in a population-derived cohort of infants; (2) establish the distribution of aIMT in early infancy; (3) compare measurement by edge-detection software to that by manual sonographic calipers; and (4) assess the effect of individual and environmental variables on image quality. Methods. Participants were term infants recruited to a population-derived birth cohort study. Transabdominal ultrasound was performed at six weeks of age by one of two trained operators. Thirty participants had ultrasounds performed by both operators on the same day. Data were collected on environmental (infant sleeping, presence of a sibling, use of sucrose, timing during study visit) and individual (post-conception age, weight, gender) variables. Two readers assessed image quality and measured aIMT by edge-detection software and a subset by manual sonographic calipers. Measurements were repeated by the same reader and between readers to obtain intra-observer and inter-observer reliability. Results: Aortic IMT was measured successfully using edge-detection in 814 infants, and 290 of these infants also had aIMT measured using manual sonographic calipers. The intra-reader intra-class correlation (ICC) (n = 20) was 0.90 (95% CI 0.76, 0.96), mean difference 1.5 μm (95% LOA -39, 59). The between reader ICC using edge-detection (n = 20) was 0.92 (95% CI 0.82, 0.97) mean difference 2 μm (95% LOA -45.0, 49.0) and with manual caliper measurement (n = 290) the ICC was 0.84 (95% CI 0.80, 0.87) mean difference 5 μm (95% LOA -51.8, 61.8). Edge-detection measurements were greater than those from manual sonographic calipers (mean aIMT 618 μm (50) versus mean aIMT 563 μm (49) respectively; p < 0.001, mean difference 44 μm, 95% LOA -54, 142). With the exception of infant crying (p = 0.001), no associations were observed between individual and environmental variables and image quality. Conclusion: In a population-derived cohort of term infants, aIMT measurement has a high level of intra and inter-reader reproducibility. Measurement of aIMT using edge-detection software gives higher inter-reader ICC than manual sonographic calipers. Image quality is not substantially affected by individual and environmental factors. © 2014 McCloskey et al.; licensee BioMed Central Ltd.
Language eng
DOI 10.1186/1476-7120-12-18
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, BioMed Central
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072355

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.