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The effect of known cardiovascular risk factors on carotid-femoral pulse wave velocity in school-aged children: a population based twin study

McCloskey, K., Sun, C., Pezic, A., Cochrane, J., Morley, R., Vuillermin, P., Burgner, D., Dwyer, T. and Ponsonby, A-L. 2014, The effect of known cardiovascular risk factors on carotid-femoral pulse wave velocity in school-aged children: a population based twin study, Journal of developmental origins of health and disease, vol. 5, no. 4, pp. 307-313, doi: 10.1017/S2040174414000282.

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Title The effect of known cardiovascular risk factors on carotid-femoral pulse wave velocity in school-aged children: a population based twin study
Author(s) McCloskey, K.
Sun, C.
Pezic, A.
Cochrane, J.
Morley, R.
Vuillermin, P.
Burgner, D.
Dwyer, T.
Ponsonby, A-L.
Journal name Journal of developmental origins of health and disease
Volume number 5
Issue number 4
Start page 307
End page 313
Total pages 7
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2014-08
ISSN 2040-1752
Keyword(s) cardiovascular risk factors
endothelial dysfunction
fetal origins cardiovascular disease
pulse wave velocity
twin studies
Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
Summary Childhood cardiovascular risk factors affect vascular function long before overt cardiovascular disease. Twin studies provide a unique opportunity to examine the influence of shared genetic and environmental influences on childhood cardiovascular function. We examined the relationship between birth parameters, markers of adiposity, insulin resistance, lipid profile and blood pressure and carotid-femoral pulse wave velocity (PWV), a validated non-invasive measure of arterial stiffness in a healthy cohort of school-aged twin children. PWV was performed on a population-based birth cohort of 147 twin pairs aged 7-11 years. Fasting blood samples, blood pressure and adiposity measures were collected concurrently. Mixed linear regression models were used to account for twin clustering, within- and between-twin pair associations. There were positive associations between both markers of higher adiposity, insulin resistance, elevated triglycerides and PWV, which remained significant after accounting for twin birth-set clustering. There was a positive association between both diastolic and mean arterial blood pressure and PWV in within-pair analysis in dizygotic, but not monozygotic twins, indicating genetic differences evident in dizygotic not monozygotic twins may affect these associations. Increased blood pressure, triglycerides and other metabolic markers are associated with increased PWV in school-aged twins. These results support both the genetic and environmental contribution to higher PWV, as a marker of arterial stiffness, and reiterate the importance of preventing metabolic syndrome from childhood.
Language eng
DOI 10.1017/S2040174414000282
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Cambridge University Press
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Document type: Journal Article
Collection: School of Medicine
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