Accepting risk in the acceleration of drug development for rare cancers.

Ashley,D, Thomas,D, Gore,L, Carter,R, Zalcberg,JR, Otmar,R and Savulescu,J 2015, Accepting risk in the acceleration of drug development for rare cancers., Lancet Oncology, vol. 16, no. 4, pp. e190-e194, doi: 10.1016/S1470-2045(14)71153-2.

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Title Accepting risk in the acceleration of drug development for rare cancers.
Author(s) Ashley,D
Thomas,D
Gore,L
Carter,RORCID iD for Carter,R orcid.org/0000-0002-1586-5619
Zalcberg,JR
Otmar,R
Savulescu,J
Journal name Lancet Oncology
Volume number 16
Issue number 4
Start page e190
End page e194
Publisher Elsevier
Place of publication England
Publication date 2015-04
ISSN 1474-5488
Summary Rare cancers collectively contribute a disproportionate fraction of the total burden of cancer. The oncology community is increasingly facing small numbers of patients with each cancer subtype, requiring cooperation and collaboration to complete multicentre trials that advance knowledge and patient care. At the same time, new insights into the biology of rare cancers have led to an explosion in knowledge and development of targeted agents. These insights and techniques are set to revolutionise the care of patients with cancer. However, drug development strategies and the availability of new agents for rare cancers are at risk of stalling owing to the ever-increasing complexity and costs of clinical trials. Finding solutions to these problems is imperative to the future of cancer care. We propose that a greater degree of risk sharing is needed than is currently accepted to enable the use of new methods with confidence, and to keep pace with scientific advancement.
Language eng
DOI 10.1016/S1470-2045(14)71153-2
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072357

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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