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Microfluidic platforms for biomarker analysis

Nahavandi, Sofia, Baratchi, Sara, Soffe, Rebecca, Tang, Shi-Yang, Nahavandi, Saeid, Mitchell, Arnan and Khoshmanesh, Khashayar 2014, Microfluidic platforms for biomarker analysis, Lab on a chip, vol. 14, no. 9, pp. 1496-1514, doi: 10.1039/c3lc51124c.

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Title Microfluidic platforms for biomarker analysis
Author(s) Nahavandi, Sofia
Baratchi, Sara
Soffe, Rebecca
Tang, Shi-Yang
Nahavandi, SaeidORCID iD for Nahavandi, Saeid orcid.org/0000-0002-0360-5270
Mitchell, Arnan
Khoshmanesh, Khashayar
Journal name Lab on a chip
Volume number 14
Issue number 9
Start page 1496
End page 1514
Total pages 19
Publisher RSC Publications
Place of publication Cambridge, Eng.
Publication date 2014
ISSN 1473-0189
Keyword(s) Biological Markers
Humans
Microfluidic Analytical Techniques
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Chemistry, Multidisciplinary
Nanoscience & Nanotechnology
Biochemistry & Molecular Biology
Chemistry
Science & Technology - Other Topics
RESPIRATORY-TRACT INFECTIONS
RAPID DIAGNOSTIC-TEST
SURROGATE END-POINTS
OF-CARE TESTS
COLORECTAL-CANCER
LUNG-CANCER
PROSTATE-CANCER
TUMOR-MARKERS
NUCLEIC-ACID
CARDIOVASCULAR-DISEASE
Summary Biomarkers have been described as characteristics, most often molecular, that provide information about biological states, whether normal, pathological, or therapeutically modified. They hold great potential to assist diagnosis and prognosis, monitor disease, and assess therapeutic effectiveness. While a few biomarkers are routinely utilised clinically, these only reflect a very small percentage of all biomarkers discovered. Numerous factors contribute to the slow uptake of these new biomarkers, with challenges faced throughout the biomarker development pipeline. Microfluidics offers two important opportunities to the field of biomarkers: firstly, it can address some of these developmental obstacles, and secondly, it can provide the precise and complex platform required to bridge the gap between biomarker research and the biomarker-based analytical device market. Indeed, adoption of microfluidics has provided a new avenue for advancement, promoting clinical utilisation of both biomarkers and their analytical platforms. This review will discuss biomarkers and outline microfluidic platforms developed for biomarker analysis.
Language eng
DOI 10.1039/c3lc51124c
Field of Research 091306 Microelectromechanical Systems (MEMS)
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, RSC Publications
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072360

Document type: Journal Article
Collection: Centre for Intelligent Systems Research
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