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Microfluidic platforms for the investigation of intercellular signalling mechanisms

Nahavandi,Sofia, Tang,SY, Baratchi,S, Soffe,R, Nahavandi,Saeid, Kalantar-zadeh,K, Mitchell,A and Khoshmanesh,K 2014, Microfluidic platforms for the investigation of intercellular signalling mechanisms, Small, vol. 10, no. 23, pp. 4810-4826, doi: 10.1002/smll.201401444.

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Title Microfluidic platforms for the investigation of intercellular signalling mechanisms
Author(s) Nahavandi,Sofia
Tang,SY
Baratchi,S
Soffe,R
Nahavandi,Saeid
Kalantar-zadeh,K
Mitchell,A
Khoshmanesh,K
Journal name Small
Volume number 10
Issue number 23
Start page 4810
End page 4826
Total pages 17
Publisher Wiley
Place of publication London, Eng.
Publication date 2014-12-10
ISSN 1613-6829
Keyword(s) cell signalling
cellular assays
microfluidics
signalling mechanisms
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
ON-A-CHIP
CELL-CELL COMMUNICATION
CHEMICAL-STIMULATION
PANCREATIC-ISLETS
GAP-JUNCTIONS
LIVING CELLS
LAMINAR-FLOW
DEVICE
SECRETION
CANCER
Summary Intercellular signalling has been identified as a highly complex process, responsible for orchestrating many physiological functions. While conventional methods of investigation have been useful, their limitations are impeding further development. Microfluidics offers an opportunity to overcome some of these limitations. Most notably, microfluidic systems can emulate the in-vivo environments. Further, they enable exceptionally precise control of the microenvironment, allowing complex mechanisms to be selectively isolated and studied in detail. There has thus been a growing adoption of microfluidic platforms for investigation of cell signalling mechanisms. This review provides an overview of the different signalling mechanisms and discusses the methods used to study them, with a focus on the microfluidic devices developed for this purpose.
Language eng
DOI 10.1002/smll.201401444
Field of Research 091306 Microelectromechanical Systems (MEMS)
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C2 Other contribution to refereed journal
ERA Research output type C Journal article
Copyright notice ©2014, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30072361

Document type: Journal Article
Collection: Centre for Intelligent Systems Research
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